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A Cytolethal Distending Toxin Variant from Aggregatibacter actinomycetemcomitans with an Aberrant CdtB That Lacks the Conserved Catalytic Histidine 160

The periodontopathogen Aggregatibacter actinomycetemcomitans synthesizes several virulence factors, including cytolethal distending toxin (CDT). The active CDT holoenzyme is an AB-type tripartite genotoxin that affects eukaryotic cells. Subunits CdtA and CdtC (B-components) allow binding and intrace...

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Detalles Bibliográficos
Autores principales:	Obradović, Davor, Gašperšič, Rok, Caserman, Simon, Leonardi, Adrijana, Jamnik, Maja, Podlesek, Zdravko, Seme, Katja, Anderluh, Gregor, Križaj, Igor, Maček, Peter, Butala, Matej
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945079/ https://www.ncbi.nlm.nih.gov/pubmed/27414641 http://dx.doi.org/10.1371/journal.pone.0159231

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