Microfluidic Cell Deformability Assay for Rapid and Efficient Kinase Screening with the CRISPR‐Cas9 System

Herein we report a CRISPR‐Cas9‐mediated loss‐of‐function kinase screen for cancer cell deformability and invasive potential in a high‐throughput microfluidic chip. In this microfluidic cell separation platform, flexible cells with high deformability and metastatic propensity flowed out, while stiff...

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Detalles Bibliográficos
Autores principales: Han, Xin, Liu, Zongbin, Zhao, Li, Wang, Feng, Yu, Yang, Yang, Jianhua, Chen, Rui, Qin, Lidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945455/
https://www.ncbi.nlm.nih.gov/pubmed/27258939
http://dx.doi.org/10.1002/anie.201601984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945455/
https://www.ncbi.nlm.nih.gov/pubmed/27258939
http://dx.doi.org/10.1002/anie.201601984

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