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Microfluidic Cell Deformability Assay for Rapid and Efficient Kinase Screening with the CRISPR‐Cas9 System

Herein we report a CRISPR‐Cas9‐mediated loss‐of‐function kinase screen for cancer cell deformability and invasive potential in a high‐throughput microfluidic chip. In this microfluidic cell separation platform, flexible cells with high deformability and metastatic propensity flowed out, while stiff...

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Detalles Bibliográficos
Autores principales:	Han, Xin, Liu, Zongbin, Zhao, Li, Wang, Feng, Yu, Yang, Yang, Jianhua, Chen, Rui, Qin, Lidong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945455/ https://www.ncbi.nlm.nih.gov/pubmed/27258939 http://dx.doi.org/10.1002/anie.201601984

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