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Glucose-Induced Oxidative Stress Reduces Proliferation in Embryonic Stem Cells via FOXO3A/β-Catenin-Dependent Transcription of p21(cip1)

Embryonic stem cells (ESCs), which are derived from a peri-implantation embryo, are routinely cultured in medium containing diabetic glucose (Glc) concentrations. While pregnancy in women with pre-existing diabetes may result in small embryos, whether such high Glc levels affect ESC growth remains u...

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Detalles Bibliográficos
Autores principales:	McClelland Descalzo, Darcie L., Satoorian, Tiffany S., Walker, Lauren M., Sparks, Nicole R.L., Pulyanina, Polina Y., zur Nieden, Nicole I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945584/ https://www.ncbi.nlm.nih.gov/pubmed/27411103 http://dx.doi.org/10.1016/j.stemcr.2016.06.006

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