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Mapping Multiplex Hubs in Human Functional Brain Networks

Typical brain networks consist of many peripheral regions and a few highly central ones, i.e., hubs, playing key functional roles in cerebral inter-regional interactions. Studies have shown that networks, obtained from the analysis of specific frequency components of brain activity, present peculiar...

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Autores principales: De Domenico, Manlio, Sasai, Shuntaro, Arenas, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945645/
https://www.ncbi.nlm.nih.gov/pubmed/27471443
http://dx.doi.org/10.3389/fnins.2016.00326
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author De Domenico, Manlio
Sasai, Shuntaro
Arenas, Alex
author_facet De Domenico, Manlio
Sasai, Shuntaro
Arenas, Alex
author_sort De Domenico, Manlio
collection PubMed
description Typical brain networks consist of many peripheral regions and a few highly central ones, i.e., hubs, playing key functional roles in cerebral inter-regional interactions. Studies have shown that networks, obtained from the analysis of specific frequency components of brain activity, present peculiar architectures with unique profiles of region centrality. However, the identification of hubs in networks built from different frequency bands simultaneously is still a challenging problem, remaining largely unexplored. Here we identify each frequency component with one layer of a multiplex network and face this challenge by exploiting the recent advances in the analysis of multiplex topologies. First, we show that each frequency band carries unique topological information, fundamental to accurately model brain functional networks. We then demonstrate that hubs in the multiplex network, in general different from those ones obtained after discarding or aggregating the measured signals as usual, provide a more accurate map of brain's most important functional regions, allowing to distinguish between healthy and schizophrenic populations better than conventional network approaches.
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spelling pubmed-49456452016-07-28 Mapping Multiplex Hubs in Human Functional Brain Networks De Domenico, Manlio Sasai, Shuntaro Arenas, Alex Front Neurosci Neuroscience Typical brain networks consist of many peripheral regions and a few highly central ones, i.e., hubs, playing key functional roles in cerebral inter-regional interactions. Studies have shown that networks, obtained from the analysis of specific frequency components of brain activity, present peculiar architectures with unique profiles of region centrality. However, the identification of hubs in networks built from different frequency bands simultaneously is still a challenging problem, remaining largely unexplored. Here we identify each frequency component with one layer of a multiplex network and face this challenge by exploiting the recent advances in the analysis of multiplex topologies. First, we show that each frequency band carries unique topological information, fundamental to accurately model brain functional networks. We then demonstrate that hubs in the multiplex network, in general different from those ones obtained after discarding or aggregating the measured signals as usual, provide a more accurate map of brain's most important functional regions, allowing to distinguish between healthy and schizophrenic populations better than conventional network approaches. Frontiers Media S.A. 2016-07-15 /pmc/articles/PMC4945645/ /pubmed/27471443 http://dx.doi.org/10.3389/fnins.2016.00326 Text en Copyright © 2016 De Domenico, Sasai and Arenas. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
De Domenico, Manlio
Sasai, Shuntaro
Arenas, Alex
Mapping Multiplex Hubs in Human Functional Brain Networks
title Mapping Multiplex Hubs in Human Functional Brain Networks
title_full Mapping Multiplex Hubs in Human Functional Brain Networks
title_fullStr Mapping Multiplex Hubs in Human Functional Brain Networks
title_full_unstemmed Mapping Multiplex Hubs in Human Functional Brain Networks
title_short Mapping Multiplex Hubs in Human Functional Brain Networks
title_sort mapping multiplex hubs in human functional brain networks
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945645/
https://www.ncbi.nlm.nih.gov/pubmed/27471443
http://dx.doi.org/10.3389/fnins.2016.00326
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