NIK regulates MT1-MMP activity and promotes glioma cell invasion independently of the canonical NF-κB pathway

A growing body of evidence implicates the noncanonical NF-κB pathway as a key driver of glioma invasiveness and a major factor underlying poor patient prognoses. Here, we show that NF-κB-inducing kinase (NIK/MAP3K14), a critical upstream regulator of the noncanonical NF-κB pathway, is both necessary...

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Detalles Bibliográficos
Autores principales: Duran, C L, Lee, D W, Jung, J-U, Ravi, S, Pogue, C B, Toussaint, L G, Bayless, K J, Sitcheran, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945740/
https://www.ncbi.nlm.nih.gov/pubmed/27270613
http://dx.doi.org/10.1038/oncsis.2016.39

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