MiR-186 inhibited aerobic glycolysis in gastric cancer via HIF-1α regulation

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Deregulation of microRNAs in human malignancies has been well documented, among which microRNA-186 (miR-186) has an antiproliferative role in some carcinomas. Here we demonstrate that low expression of miR-186 facilitates aerobic glycolysis in gastric cancer. MiR-186 suppresses cell proliferation in...

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Detalles Bibliográficos
Autores principales: Liu, L, Wang, Y, Bai, R, Yang, K, Tian, Z
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945752/
https://www.ncbi.nlm.nih.gov/pubmed/27159677
http://dx.doi.org/10.1038/oncsis.2016.35
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author Liu, L
Wang, Y
Bai, R
Yang, K
Tian, Z
author_facet Liu, L
Wang, Y
Bai, R
Yang, K
Tian, Z
author_sort Liu, L
collection PubMed
description Deregulation of microRNAs in human malignancies has been well documented, among which microRNA-186 (miR-186) has an antiproliferative role in some carcinomas. Here we demonstrate that low expression of miR-186 facilitates aerobic glycolysis in gastric cancer. MiR-186 suppresses cell proliferation induced by hypoxia inducible factor 1 alpha (HIF-1α) in gastric cancer cell lines MKN45 and SGC7901. Cellular glycolysis, including cellular glucose uptake, lactate, ATP/ADP and NAD+/NADH ratios, are also inhibited by miR-186. The negative regulation of miR-186 on HIF-1α effects its downstream targets, including programmed death ligand 1 and two glycolytic key enzymes, hexokinase 2 and platelet-type phosphofructokinase. The antioncogenic effects of miR-186 are proved by in vivo xenograft tumor experiment. The results demonstrate that the miR-186/HIF-1α axis has an antioncogenic role in gastric cancer.
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spelling pubmed-49457522017-01-17 MiR-186 inhibited aerobic glycolysis in gastric cancer via HIF-1α regulation Liu, L Wang, Y Bai, R Yang, K Tian, Z Oncogenesis Original Article Deregulation of microRNAs in human malignancies has been well documented, among which microRNA-186 (miR-186) has an antiproliferative role in some carcinomas. Here we demonstrate that low expression of miR-186 facilitates aerobic glycolysis in gastric cancer. MiR-186 suppresses cell proliferation induced by hypoxia inducible factor 1 alpha (HIF-1α) in gastric cancer cell lines MKN45 and SGC7901. Cellular glycolysis, including cellular glucose uptake, lactate, ATP/ADP and NAD+/NADH ratios, are also inhibited by miR-186. The negative regulation of miR-186 on HIF-1α effects its downstream targets, including programmed death ligand 1 and two glycolytic key enzymes, hexokinase 2 and platelet-type phosphofructokinase. The antioncogenic effects of miR-186 are proved by in vivo xenograft tumor experiment. The results demonstrate that the miR-186/HIF-1α axis has an antioncogenic role in gastric cancer. Nature Publishing Group 2016-05 2016-05-09 /pmc/articles/PMC4945752/ /pubmed/27159677 http://dx.doi.org/10.1038/oncsis.2016.35 Text en Copyright © 2016 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Original Article
Liu, L
Wang, Y
Bai, R
Yang, K
Tian, Z
MiR-186 inhibited aerobic glycolysis in gastric cancer via HIF-1α regulation
title MiR-186 inhibited aerobic glycolysis in gastric cancer via HIF-1α regulation
title_full MiR-186 inhibited aerobic glycolysis in gastric cancer via HIF-1α regulation
title_fullStr MiR-186 inhibited aerobic glycolysis in gastric cancer via HIF-1α regulation
title_full_unstemmed MiR-186 inhibited aerobic glycolysis in gastric cancer via HIF-1α regulation
title_short MiR-186 inhibited aerobic glycolysis in gastric cancer via HIF-1α regulation
title_sort mir-186 inhibited aerobic glycolysis in gastric cancer via hif-1α regulation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945752/
https://www.ncbi.nlm.nih.gov/pubmed/27159677
http://dx.doi.org/10.1038/oncsis.2016.35
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