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Germline MC1R status influences somatic mutation burden in melanoma

The major genetic determinants of cutaneous melanoma risk in the general population are disruptive variants (R alleles) in the melanocortin 1 receptor (MC1R) gene. These alleles are also linked to red hair, freckling, and sun sensitivity, all of which are known melanoma phenotypic risk factors. Here...

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Detalles Bibliográficos
Autores principales:	Robles-Espinoza, Carla Daniela, Roberts, Nicola D., Chen, Shuyang, Leacy, Finbarr P., Alexandrov, Ludmil B., Pornputtapong, Natapol, Halaban, Ruth, Krauthammer, Michael, Cui, Rutao, Timothy Bishop, D., Adams, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945874/ https://www.ncbi.nlm.nih.gov/pubmed/27403562 http://dx.doi.org/10.1038/ncomms12064

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