Cargando…

An Alzheimer’s Disease Genetic Risk Score Predicts Longitudinal Thinning of Hippocampal Complex Subregions in Healthy Older Adults

Variants at 21 genetic loci have been associated with an increased risk for Alzheimer’s disease (AD). An important unresolved question is whether multiple genetic risk factors can be combined to increase the power to detect changes in neuroimaging biomarkers for AD. We acquired high-resolution struc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Harrison, Theresa M., Mahmood, Zanjbeel, Lau, Edward P., Karacozoff, Alexandra M., Burggren, Alison C., Small, Gary W., Bookheimer, Susan Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2016
Materias:	Methods/New Tools
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945997/ https://www.ncbi.nlm.nih.gov/pubmed/27482534 http://dx.doi.org/10.1523/ENEURO.0098-16.2016

Ejemplares similares

Subregional Hippocampal Thickness Abnormalities in Older Adults with a History of Heavy Cannabis Use
por: Burggren, Alison C., et al.
Publicado: (2018)

Chemogenetic Activation of Excitatory Neurons Alters Hippocampal Neurotransmission in a Dose-Dependent Manner
por: Pati, Sthitapranjya, et al.
Publicado: (2019)

Tetrode Recording from the Hippocampus of Behaving Mice Coupled with Four-Point-Irradiation Closed-Loop Optogenetics: A Technique to Study the Contribution of Hippocampal SWR Events to Learning
por: Rangel Guerrero, Dámaris K., et al.
Publicado: (2018)

Fluorescence-Based Quantitative Synapse Analysis for Cell Type-Specific Connectomics
por: Kuljis, Dika A., et al.
Publicado: (2019)

3D Imaging of Axons in Transparent Spinal Cords from Rodents and Nonhuman Primates1,2,3
por: Soderblom, Cynthia, et al.
Publicado: (2015)

Realistic Numerical and Analytical Modeling of Light Scattering in Brain Tissue for Optogenetic Applications123
por: Yona, Guy, et al.
Publicado: (2016)

Localization of Metal Electrodes in the Intact Rat Brain Using Registration of 3D Microcomputed Tomography Images to a Magnetic Resonance Histology Atlas1,2,3
por: Borg, Jana Schaich, et al.
Publicado: (2015)

Measurement of Retinal Blood Flow Using Fluorescently Labeled Red Blood Cells1,2,3
por: Kornfield, Tess E., et al.
Publicado: (2015)

In Vivo Two-Photon Imaging of Dendritic Spines in Marmoset Neocortex1,2,3
por: Sadakane, Osamu, et al.
Publicado: (2015)

Sleep in Populations of Drosophila Melanogaster1,2,3
por: Liu, Chang, et al.
Publicado: (2015)

neuTube 1.0: A New Design for Efficient Neuron Reconstruction Software Based on the SWC Format 123
por: Feng, Linqing, et al.
Publicado: (2015)

Optimization of CLARITY for Clearing Whole-Brain and Other Intact Organs1,2,3
por: Epp, Jonathan R., et al.
Publicado: (2015)

Simultaneous Sodium and Calcium Imaging from Dendrites and Axons
por: Miyazaki, Kenichi, et al.
Publicado: (2015)

Computational Phenotyping in Psychiatry: A Worked Example
por: Schwartenbeck, Philipp, et al.
Publicado: (2016)

LSPS/Optogenetics to Improve Synaptic Connectivity Mapping: Unmasking the Role of Basket Cell-Mediated Feedforward Inhibition
por: Brill, Julia, et al.
Publicado: (2016)

Interfacing with Neural Activity via Femtosecond Laser Stimulation of Drug-Encapsulating Liposomal Nanostructures
por: Nakano, Takashi, et al.
Publicado: (2016)

Mapping Language Networks Using the Structural and Dynamic Brain Connectomes
por: Del Gaizo, John, et al.
Publicado: (2017)

ABLE: An Activity-Based Level Set Segmentation Algorithm for Two-Photon Calcium Imaging Data
por: Reynolds, Stephanie, et al.
Publicado: (2017)

Quantifying Mesoscale Neuroanatomy Using X-Ray Microtomography
por: Dyer, Eva L., et al.
Publicado: (2017)

A Dynamic Clamp on Every Rig
por: Desai, Niraj S., et al.
Publicado: (2017)

Intellicount: High-Throughput Quantification of Fluorescent Synaptic Protein Puncta by Machine Learning
por: Fantuzzo, J. A., et al.
Publicado: (2017)

Cross-Laboratory Analysis of Brain Cell Type Transcriptomes with Applications to Interpretation of Bulk Tissue Data
por: Mancarci, B. Ogan, et al.
Publicado: (2017)

Auditory Brainstem Responses to Continuous Natural Speech in Human Listeners
por: Maddox, Ross K., et al.
Publicado: (2018)

Using Automated Live Cell Imaging to Reveal Early Changes during Human Motor Neuron Degeneration
por: Shin, Hye Young, et al.
Publicado: (2018)

Extending the Time Domain of Neuronal Silencing with Cryptophyte Anion Channelrhodopsins
por: Govorunova, Elena G., et al.
Publicado: (2018)

Uncovering Neuronal Networks Defined by Consistent Between-Neuron Spike Timing from Neuronal Spike Recordings
por: van der Meij, Roemer, et al.
Publicado: (2018)

Aberrant Cortical Activity in Multiple GCaMP6-Expressing Transgenic Mouse Lines
por: Steinmetz, Nicholas A., et al.
Publicado: (2017)

Assessing the Impacts of Correlated Variability with Dissociated Timescales
por: Takahashi, Toshiyuki, et al.
Publicado: (2019)

A Neuron-Optimized CRISPR/dCas9 Activation System for Robust and Specific Gene Regulation
por: Savell, Katherine E., et al.
Publicado: (2019)

Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay
por: Baldo, Barbara, et al.
Publicado: (2018)

Simultaneous Assessment of Homonymous and Heteronymous Monosynaptic Reflex Excitability in the Adult Rat
por: Smith, Calvin C., et al.
Publicado: (2018)

Functional Categories of Visuomotor Neurons in Macaque Frontal Eye Field
por: Lowe, Kaleb A., et al.
Publicado: (2018)

Immediate-Early Promoter-Driven Transgenic Reporter System for Neuroethological Research in a Hemimetabolous Insect
por: Watanabe, Takayuki, et al.
Publicado: (2018)

Electrophysiological Signature Reveals Laminar Structure of the Porcine Hippocampus
por: Ulyanova, Alexandra V., et al.
Publicado: (2018)

High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons
por: Parker, Sara S., et al.
Publicado: (2018)

Automatic Cell Segmentation by Adaptive Thresholding (ACSAT) for Large-Scale Calcium Imaging Datasets
por: Shen, Simon P., et al.
Publicado: (2018)

High-Fidelity Imaging in Brain-Wide Structural Studies Using Light-Sheet Microscopy
por: Müllenbroich, M. Caroline, et al.
Publicado: (2018)

3DMorph Automatic Analysis of Microglial Morphology in Three Dimensions from Ex Vivo and In Vivo Imaging
por: York, Elisa M., et al.
Publicado: (2018)

Real-Time Neurofeedback to Modulate β-Band Power in the Subthalamic Nucleus in Parkinson’s Disease Patients
por: Fukuma, Ryohei, et al.
Publicado: (2018)

Embryonic Neocortical Microglia Express Toll-Like Receptor 9 and Respond to Plasmid DNA Injected into the Ventricle: Technical Considerations Regarding Microglial Distribution in Electroporated Brain Walls
por: Hattori, Yuki, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3f6l2kt4b5t1fogiuu0tgv13pu