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Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits

BACKGROUND: Atypical lateralization of language-related functions has been repeatedly found in individuals with autism spectrum conditions (ASC). Few studies have, however, investigated deviations from typically occurring asymmetry of other lateralized cognitive and behavioural domains. Motor defici...

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Autores principales: Floris, Dorothea L., Barber, Anita D., Nebel, Mary Beth, Martinelli, Mary, Lai, Meng-Chuan, Crocetti, Deana, Baron-Cohen, Simon, Suckling, John, Pekar, James J., Mostofsky, Stewart H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946094/
https://www.ncbi.nlm.nih.gov/pubmed/27429731
http://dx.doi.org/10.1186/s13229-016-0096-6
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author Floris, Dorothea L.
Barber, Anita D.
Nebel, Mary Beth
Martinelli, Mary
Lai, Meng-Chuan
Crocetti, Deana
Baron-Cohen, Simon
Suckling, John
Pekar, James J.
Mostofsky, Stewart H.
author_facet Floris, Dorothea L.
Barber, Anita D.
Nebel, Mary Beth
Martinelli, Mary
Lai, Meng-Chuan
Crocetti, Deana
Baron-Cohen, Simon
Suckling, John
Pekar, James J.
Mostofsky, Stewart H.
author_sort Floris, Dorothea L.
collection PubMed
description BACKGROUND: Atypical lateralization of language-related functions has been repeatedly found in individuals with autism spectrum conditions (ASC). Few studies have, however, investigated deviations from typically occurring asymmetry of other lateralized cognitive and behavioural domains. Motor deficits are among the earliest and most prominent symptoms in individuals with ASC and precede core social and communicative symptoms. METHODS: Here, we investigate whether motor circuit connectivity is (1) atypically lateralized in children with ASC and (2) whether this relates to core autistic symptoms and motor performance. Participants comprised 44 right-handed high-functioning children with autism (36 males, 8 females) and 80 typically developing control children (58 males, 22 females) matched on age, sex and performance IQ. We examined lateralization of functional motor circuit connectivity based on homotopic seeds derived from peak activations during a finger tapping paradigm. Motor performance was assessed using the Physical and Neurological Examination for Subtle Signs (PANESS). RESULTS: Children with ASC showed rightward lateralization in mean motor circuit connectivity compared to typically developing children, and this was associated with poorer performance on all three PANESS measures. CONCLUSIONS: Our findings reveal that atypical lateralization in ASC is not restricted to language functions but is also present in circuits subserving motor functions and may underlie motor deficits in children with ASC. Future studies should investigate whether this is an age-invariant finding extending to adolescents and adults and whether these asymmetries relate to atypical lateralization in the language domain. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13229-016-0096-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-49460942016-07-16 Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits Floris, Dorothea L. Barber, Anita D. Nebel, Mary Beth Martinelli, Mary Lai, Meng-Chuan Crocetti, Deana Baron-Cohen, Simon Suckling, John Pekar, James J. Mostofsky, Stewart H. Mol Autism Research BACKGROUND: Atypical lateralization of language-related functions has been repeatedly found in individuals with autism spectrum conditions (ASC). Few studies have, however, investigated deviations from typically occurring asymmetry of other lateralized cognitive and behavioural domains. Motor deficits are among the earliest and most prominent symptoms in individuals with ASC and precede core social and communicative symptoms. METHODS: Here, we investigate whether motor circuit connectivity is (1) atypically lateralized in children with ASC and (2) whether this relates to core autistic symptoms and motor performance. Participants comprised 44 right-handed high-functioning children with autism (36 males, 8 females) and 80 typically developing control children (58 males, 22 females) matched on age, sex and performance IQ. We examined lateralization of functional motor circuit connectivity based on homotopic seeds derived from peak activations during a finger tapping paradigm. Motor performance was assessed using the Physical and Neurological Examination for Subtle Signs (PANESS). RESULTS: Children with ASC showed rightward lateralization in mean motor circuit connectivity compared to typically developing children, and this was associated with poorer performance on all three PANESS measures. CONCLUSIONS: Our findings reveal that atypical lateralization in ASC is not restricted to language functions but is also present in circuits subserving motor functions and may underlie motor deficits in children with ASC. Future studies should investigate whether this is an age-invariant finding extending to adolescents and adults and whether these asymmetries relate to atypical lateralization in the language domain. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13229-016-0096-6) contains supplementary material, which is available to authorized users. BioMed Central 2016-07-14 /pmc/articles/PMC4946094/ /pubmed/27429731 http://dx.doi.org/10.1186/s13229-016-0096-6 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Floris, Dorothea L.
Barber, Anita D.
Nebel, Mary Beth
Martinelli, Mary
Lai, Meng-Chuan
Crocetti, Deana
Baron-Cohen, Simon
Suckling, John
Pekar, James J.
Mostofsky, Stewart H.
Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits
title Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits
title_full Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits
title_fullStr Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits
title_full_unstemmed Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits
title_short Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits
title_sort atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946094/
https://www.ncbi.nlm.nih.gov/pubmed/27429731
http://dx.doi.org/10.1186/s13229-016-0096-6
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