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Local and global patterns of admixture and population structure in Iranian native cattle

BACKGROUND: Two separate domestication events gave rise to humped zebu cattle in India and humpless taurine cattle in the Fertile Crescent of the Near and Middle East. Iran covers the Eastern side of the Fertile Crescent and exhibits a variety of native cattle breeds, however, only little is known a...

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Autores principales: Karimi, Karim, Strucken, Eva M., Moghaddar, Nasir, Ferdosi, Mohammad H., Esmailizadeh, Ali, Gondro, Cedric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946207/
https://www.ncbi.nlm.nih.gov/pubmed/27418004
http://dx.doi.org/10.1186/s12863-016-0416-z
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author Karimi, Karim
Strucken, Eva M.
Moghaddar, Nasir
Ferdosi, Mohammad H.
Esmailizadeh, Ali
Gondro, Cedric
author_facet Karimi, Karim
Strucken, Eva M.
Moghaddar, Nasir
Ferdosi, Mohammad H.
Esmailizadeh, Ali
Gondro, Cedric
author_sort Karimi, Karim
collection PubMed
description BACKGROUND: Two separate domestication events gave rise to humped zebu cattle in India and humpless taurine cattle in the Fertile Crescent of the Near and Middle East. Iran covers the Eastern side of the Fertile Crescent and exhibits a variety of native cattle breeds, however, only little is known about the admixture patterns of Iranian cattle and their contribution to the formation of modern cattle breeds. RESULTS: Genome-wide data (700 k chip) of eight Iranian cattle breeds (Sarabi N = 19, Kurdi N = 7, Taleshi N = 7, Mazandarani N = 10, Najdi N = 7, Pars N = 7, Kermani N = 9, and Sistani N = 9) were collected from across Iran. For a local assessment, taurine (Holstein and Jersey) and indicine (Brahman) outgroup samples were used. For the global perspective, 134 world-wide cattle breeds were included. Between breed variation amongst Iranian cattle explained 60 % (p < 0.001) of the total molecular variation and 82.88 % (p < 0.001) when outgroups were included. Several migration edges were observed within the Iranian cattle breeds. The highest indicine proportion was found in Sistani. All Iranian breeds with higher indicine ancestry were more admixed with a complex migration pattern. Nineteen founder populations most accurately explained the admixture of 44 selected representative cattle breeds (standard error 0.4617). Low levels of African ancestry were identified in Iranian cattle breeds (on average 7.5 %); however, the signal did not persist through all analyses. Admixture and migration analyses revealed minimal introgression from Iranian cattle into other taurine cattle (Holstein, Hanwoo, Anatolian breeds). CONCLUSION: The eight Iranian cattle breeds feature a discrete genetic composition which should be considered in conservation programs aimed at preserving unique species and genetic diversity. Despite a complex admixture pattern among Iranian cattle breeds, there was no strong introgression from other world-wide cattle breeds into Iranian cattle and vice versa. Considering Iran’s central location of cattle domestication, Iranian cattle might represent a local domestication event that remained contained and did not contribute to the formation of modern breeds, or genetics of the ancestral population that gave rise to modern cattle is too diluted to be linked directly to any current cattle breeds. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12863-016-0416-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-49462072016-07-16 Local and global patterns of admixture and population structure in Iranian native cattle Karimi, Karim Strucken, Eva M. Moghaddar, Nasir Ferdosi, Mohammad H. Esmailizadeh, Ali Gondro, Cedric BMC Genet Research Article BACKGROUND: Two separate domestication events gave rise to humped zebu cattle in India and humpless taurine cattle in the Fertile Crescent of the Near and Middle East. Iran covers the Eastern side of the Fertile Crescent and exhibits a variety of native cattle breeds, however, only little is known about the admixture patterns of Iranian cattle and their contribution to the formation of modern cattle breeds. RESULTS: Genome-wide data (700 k chip) of eight Iranian cattle breeds (Sarabi N = 19, Kurdi N = 7, Taleshi N = 7, Mazandarani N = 10, Najdi N = 7, Pars N = 7, Kermani N = 9, and Sistani N = 9) were collected from across Iran. For a local assessment, taurine (Holstein and Jersey) and indicine (Brahman) outgroup samples were used. For the global perspective, 134 world-wide cattle breeds were included. Between breed variation amongst Iranian cattle explained 60 % (p < 0.001) of the total molecular variation and 82.88 % (p < 0.001) when outgroups were included. Several migration edges were observed within the Iranian cattle breeds. The highest indicine proportion was found in Sistani. All Iranian breeds with higher indicine ancestry were more admixed with a complex migration pattern. Nineteen founder populations most accurately explained the admixture of 44 selected representative cattle breeds (standard error 0.4617). Low levels of African ancestry were identified in Iranian cattle breeds (on average 7.5 %); however, the signal did not persist through all analyses. Admixture and migration analyses revealed minimal introgression from Iranian cattle into other taurine cattle (Holstein, Hanwoo, Anatolian breeds). CONCLUSION: The eight Iranian cattle breeds feature a discrete genetic composition which should be considered in conservation programs aimed at preserving unique species and genetic diversity. Despite a complex admixture pattern among Iranian cattle breeds, there was no strong introgression from other world-wide cattle breeds into Iranian cattle and vice versa. Considering Iran’s central location of cattle domestication, Iranian cattle might represent a local domestication event that remained contained and did not contribute to the formation of modern breeds, or genetics of the ancestral population that gave rise to modern cattle is too diluted to be linked directly to any current cattle breeds. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12863-016-0416-z) contains supplementary material, which is available to authorized users. BioMed Central 2016-07-15 /pmc/articles/PMC4946207/ /pubmed/27418004 http://dx.doi.org/10.1186/s12863-016-0416-z Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Karimi, Karim
Strucken, Eva M.
Moghaddar, Nasir
Ferdosi, Mohammad H.
Esmailizadeh, Ali
Gondro, Cedric
Local and global patterns of admixture and population structure in Iranian native cattle
title Local and global patterns of admixture and population structure in Iranian native cattle
title_full Local and global patterns of admixture and population structure in Iranian native cattle
title_fullStr Local and global patterns of admixture and population structure in Iranian native cattle
title_full_unstemmed Local and global patterns of admixture and population structure in Iranian native cattle
title_short Local and global patterns of admixture and population structure in Iranian native cattle
title_sort local and global patterns of admixture and population structure in iranian native cattle
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946207/
https://www.ncbi.nlm.nih.gov/pubmed/27418004
http://dx.doi.org/10.1186/s12863-016-0416-z
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