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Fermented rice bran prevents atopic dermatitis in DNCB-treated NC/Nga mice

The fermentation of natural plants has a favorable effect on the functional and biological activities of living systems. These include anti-oxidative, anti-inflammatory, and anti-platelet aggregation activities. This is attributed to the chemical conversion of the parent plants to functional constit...

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Autores principales: Saba, Evelyn, Lee, Chun Hee, Jeong, Da Hye, Lee, Kija, Kim, Tae-Hwan, Roh, Seong-Soo, Kim, Seung-Hyung, Rhee, Man Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Department of Journal of Biomedical Research 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946324/
https://www.ncbi.nlm.nih.gov/pubmed/27323667
http://dx.doi.org/10.7555/JBR.30.2016K0001
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author Saba, Evelyn
Lee, Chun Hee
Jeong, Da Hye
Lee, Kija
Kim, Tae-Hwan
Roh, Seong-Soo
Kim, Seung-Hyung
Rhee, Man Hee
author_facet Saba, Evelyn
Lee, Chun Hee
Jeong, Da Hye
Lee, Kija
Kim, Tae-Hwan
Roh, Seong-Soo
Kim, Seung-Hyung
Rhee, Man Hee
author_sort Saba, Evelyn
collection PubMed
description The fermentation of natural plants has a favorable effect on the functional and biological activities of living systems. These include anti-oxidative, anti-inflammatory, and anti-platelet aggregation activities. This is attributed to the chemical conversion of the parent plants to functional constituents, which show more potent biological activity. In our study, rice bran along with oriental medicinal plants (Angelicae gigantis, Cnidium officinale, Artemisia princeps, and Camellia sinensis) was fermented by Lactobacillus rhamnosus and Pichia deserticola (FRBE). We evaluated the effects of oral administration of FRBE on atopic dermatitis in 1-chloro-2,4-dinitrobenzene (DNCB)-treated NC/Nga mice. FRBE significantly ameliorated the macroscopic and microscopic appearance of skin lesions in DNCB-induced atopic dermatitis and reduced levels of serum immunoglobulin E and the differential white blood cell count. In addition, it reduced skin thickness compared to that of atopic dermatitis-affected skin. FRBE treatment also reduced mast cell incorporation in skin lesions of atopic dermatitis. The total cell number in dorsal skin tissue and the axillary lymph node increased following DNCB application, and this was normalized by FRBE treatment. Moreover, it decreased the levels of CD8(+) helper T cells and Gr-1(+)/CD11b(+) B cells in peripheral blood mononuclear cells and skin lesions in DNCB-induced atopic dermatitis. Using real-time polymerase chain reaction analysis, we demonstrated that FRBE significantly inhibited mRNA expression of cytokines (e.g., interleukin-5 and interleukin-13) and cyclooxygenase-2 in AD skin lesions. These results suggest that FRBE could be a valuable herbal remedy for the treatment of atopic dermatitis.
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spelling pubmed-49463242016-07-25 Fermented rice bran prevents atopic dermatitis in DNCB-treated NC/Nga mice Saba, Evelyn Lee, Chun Hee Jeong, Da Hye Lee, Kija Kim, Tae-Hwan Roh, Seong-Soo Kim, Seung-Hyung Rhee, Man Hee J Biomed Res Original Article The fermentation of natural plants has a favorable effect on the functional and biological activities of living systems. These include anti-oxidative, anti-inflammatory, and anti-platelet aggregation activities. This is attributed to the chemical conversion of the parent plants to functional constituents, which show more potent biological activity. In our study, rice bran along with oriental medicinal plants (Angelicae gigantis, Cnidium officinale, Artemisia princeps, and Camellia sinensis) was fermented by Lactobacillus rhamnosus and Pichia deserticola (FRBE). We evaluated the effects of oral administration of FRBE on atopic dermatitis in 1-chloro-2,4-dinitrobenzene (DNCB)-treated NC/Nga mice. FRBE significantly ameliorated the macroscopic and microscopic appearance of skin lesions in DNCB-induced atopic dermatitis and reduced levels of serum immunoglobulin E and the differential white blood cell count. In addition, it reduced skin thickness compared to that of atopic dermatitis-affected skin. FRBE treatment also reduced mast cell incorporation in skin lesions of atopic dermatitis. The total cell number in dorsal skin tissue and the axillary lymph node increased following DNCB application, and this was normalized by FRBE treatment. Moreover, it decreased the levels of CD8(+) helper T cells and Gr-1(+)/CD11b(+) B cells in peripheral blood mononuclear cells and skin lesions in DNCB-induced atopic dermatitis. Using real-time polymerase chain reaction analysis, we demonstrated that FRBE significantly inhibited mRNA expression of cytokines (e.g., interleukin-5 and interleukin-13) and cyclooxygenase-2 in AD skin lesions. These results suggest that FRBE could be a valuable herbal remedy for the treatment of atopic dermatitis. Editorial Department of Journal of Biomedical Research 2016-07 2016-05-20 /pmc/articles/PMC4946324/ /pubmed/27323667 http://dx.doi.org/10.7555/JBR.30.2016K0001 Text en © 2016 by the Journal of Biomedical Research. All rights reserved.
spellingShingle Original Article
Saba, Evelyn
Lee, Chun Hee
Jeong, Da Hye
Lee, Kija
Kim, Tae-Hwan
Roh, Seong-Soo
Kim, Seung-Hyung
Rhee, Man Hee
Fermented rice bran prevents atopic dermatitis in DNCB-treated NC/Nga mice
title Fermented rice bran prevents atopic dermatitis in DNCB-treated NC/Nga mice
title_full Fermented rice bran prevents atopic dermatitis in DNCB-treated NC/Nga mice
title_fullStr Fermented rice bran prevents atopic dermatitis in DNCB-treated NC/Nga mice
title_full_unstemmed Fermented rice bran prevents atopic dermatitis in DNCB-treated NC/Nga mice
title_short Fermented rice bran prevents atopic dermatitis in DNCB-treated NC/Nga mice
title_sort fermented rice bran prevents atopic dermatitis in dncb-treated nc/nga mice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946324/
https://www.ncbi.nlm.nih.gov/pubmed/27323667
http://dx.doi.org/10.7555/JBR.30.2016K0001
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