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Delay of Treatment Initiation Does Not Adversely Affect Survival Outcome in Breast Cancer
PURPOSE: Previous studies examining the relationship between time to treatment and survival outcome in breast cancer have shown inconsistent results. The aim of this study was to analyze the overall impact of delay of treatment initiation on patient survival and to determine whether certain subgroup...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Cancer Association
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946375/ https://www.ncbi.nlm.nih.gov/pubmed/26511801 http://dx.doi.org/10.4143/crt.2015.173 |
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author | Yoo, Tae-Kyung Han, Wonshik Moon, Hyeong-Gon Kim, Jisun Lee, Jun Woo Kim, Min Kyoon Lee, Eunshin Kim, Jongjin Noh, Dong-Young |
author_facet | Yoo, Tae-Kyung Han, Wonshik Moon, Hyeong-Gon Kim, Jisun Lee, Jun Woo Kim, Min Kyoon Lee, Eunshin Kim, Jongjin Noh, Dong-Young |
author_sort | Yoo, Tae-Kyung |
collection | PubMed |
description | PURPOSE: Previous studies examining the relationship between time to treatment and survival outcome in breast cancer have shown inconsistent results. The aim of this study was to analyze the overall impact of delay of treatment initiation on patient survival and to determine whether certain subgroups require more prompt initiation of treatment. MATERIALS AND METHODS: This study is a retrospective analysis of stage I-III patients who were treated in a single tertiary institution between 2005 and 2008. Kaplan-Meier survival analysis and Cox proportional hazards regression model were used to evaluate the impact of interval between diagnosis and treatment initiation in breast cancer and various subgroups. RESULTS: A total of 1,702 patients were included. Factors associated with longer delay of treatment initiation were diagnosis at another hospital, medical comorbidities, and procedures performed before admission for surgery. An interval between diagnosis and treatment initiation as a continuous variable or with a cutoff value of 15, 30, 45, and 60 days had no impact on disease-free survival (DFS). Subgroup analyses for hormone-responsiveness, triple-negative breast cancer, young age, clinical stage, and type of initial treatment showed no significant association between longer delay of treatment initiation and DFS. CONCLUSION: Our results show that an interval between diagnosis and treatment initiation of 60 days or shorter does not appear to adversely affect DFS in breast cancer. |
format | Online Article Text |
id | pubmed-4946375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Korean Cancer Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-49463752016-07-18 Delay of Treatment Initiation Does Not Adversely Affect Survival Outcome in Breast Cancer Yoo, Tae-Kyung Han, Wonshik Moon, Hyeong-Gon Kim, Jisun Lee, Jun Woo Kim, Min Kyoon Lee, Eunshin Kim, Jongjin Noh, Dong-Young Cancer Res Treat Original Article PURPOSE: Previous studies examining the relationship between time to treatment and survival outcome in breast cancer have shown inconsistent results. The aim of this study was to analyze the overall impact of delay of treatment initiation on patient survival and to determine whether certain subgroups require more prompt initiation of treatment. MATERIALS AND METHODS: This study is a retrospective analysis of stage I-III patients who were treated in a single tertiary institution between 2005 and 2008. Kaplan-Meier survival analysis and Cox proportional hazards regression model were used to evaluate the impact of interval between diagnosis and treatment initiation in breast cancer and various subgroups. RESULTS: A total of 1,702 patients were included. Factors associated with longer delay of treatment initiation were diagnosis at another hospital, medical comorbidities, and procedures performed before admission for surgery. An interval between diagnosis and treatment initiation as a continuous variable or with a cutoff value of 15, 30, 45, and 60 days had no impact on disease-free survival (DFS). Subgroup analyses for hormone-responsiveness, triple-negative breast cancer, young age, clinical stage, and type of initial treatment showed no significant association between longer delay of treatment initiation and DFS. CONCLUSION: Our results show that an interval between diagnosis and treatment initiation of 60 days or shorter does not appear to adversely affect DFS in breast cancer. Korean Cancer Association 2016-07 2015-10-22 /pmc/articles/PMC4946375/ /pubmed/26511801 http://dx.doi.org/10.4143/crt.2015.173 Text en Copyright © 2016 by the Korean Cancer Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yoo, Tae-Kyung Han, Wonshik Moon, Hyeong-Gon Kim, Jisun Lee, Jun Woo Kim, Min Kyoon Lee, Eunshin Kim, Jongjin Noh, Dong-Young Delay of Treatment Initiation Does Not Adversely Affect Survival Outcome in Breast Cancer |
title | Delay of Treatment Initiation Does Not Adversely Affect Survival Outcome in Breast Cancer |
title_full | Delay of Treatment Initiation Does Not Adversely Affect Survival Outcome in Breast Cancer |
title_fullStr | Delay of Treatment Initiation Does Not Adversely Affect Survival Outcome in Breast Cancer |
title_full_unstemmed | Delay of Treatment Initiation Does Not Adversely Affect Survival Outcome in Breast Cancer |
title_short | Delay of Treatment Initiation Does Not Adversely Affect Survival Outcome in Breast Cancer |
title_sort | delay of treatment initiation does not adversely affect survival outcome in breast cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946375/ https://www.ncbi.nlm.nih.gov/pubmed/26511801 http://dx.doi.org/10.4143/crt.2015.173 |
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