Cargando…

Efficacy and safety of daclatasvir and asunaprevir for hepatitis C virus genotype 1b infection

BACKGROUND/AIMS: The treatment strategy for hepatitis C virus (HCV) has been changing rapidly since the introduction of direct-acting antivirals such as daclatasvir (DCV) and asunaprevir (ASV). We evaluated the efficacy and safety of DCV and ASV for HCV in real-life practice. METHODS: Patients were...

Descripción completa

Detalles Bibliográficos
Autores principales: Nam, Hee Chul, Lee, Hae Lim, Yang, Hyun, Song, Myeong Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association for the Study of the Liver 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946403/
https://www.ncbi.nlm.nih.gov/pubmed/27377910
http://dx.doi.org/10.3350/cmh.2016.0020
_version_ 1782443022638645248
author Nam, Hee Chul
Lee, Hae Lim
Yang, Hyun
Song, Myeong Jun
author_facet Nam, Hee Chul
Lee, Hae Lim
Yang, Hyun
Song, Myeong Jun
author_sort Nam, Hee Chul
collection PubMed
description BACKGROUND/AIMS: The treatment strategy for hepatitis C virus (HCV) has been changing rapidly since the introduction of direct-acting antivirals such as daclatasvir (DCV) and asunaprevir (ASV). We evaluated the efficacy and safety of DCV and ASV for HCV in real-life practice. METHODS: Patients were treated with 60 mg of DCV once daily plus 200 mg of ASV twice daily for 24 weeks, and followed for 12 weeks. The primary endpoint was a sustained virological response at 12 weeks after treatment (SVR(12)) and safety. RESULTS: This retrospective study included eight patients with chronic HCV genotype 1b infection. All of the enrolled patients were diagnosed with liver cirrhosis, and their mean age was 65.75 years. One patient was a nonresponder and two patients relapsed with previous pegylated interferon (PegIFN) and ribavirin (RBV) treatment. None of the patient showed NS5A mutation. An SVR(12) was achieved in 88% of cases by the DCV and ASV combination therapy. The serum transaminase level and the aspartate-aminotransferase-to-platelet ratio were improved after the treatment. DCV and ASV were well tolerated in most of the patients, with treatment discontinuation due to adverse events (elevated liver enzyme and decompensation) occurring in two patients. CONCLUSION: In this study, combination of DCV and ASV treatment achieved a high sustained virological response with few adverse events even in those with cirrhosis, advanced age, and nonresponse/relapse to previous interferon-based therapy. Close monitoring of safety issues may be necessary when treating chronic HCV patients receiving DCV and ASV, especially in older patient and those with cirrhosis.
format Online
Article
Text
id pubmed-4946403
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher The Korean Association for the Study of the Liver
record_format MEDLINE/PubMed
spelling pubmed-49464032016-07-18 Efficacy and safety of daclatasvir and asunaprevir for hepatitis C virus genotype 1b infection Nam, Hee Chul Lee, Hae Lim Yang, Hyun Song, Myeong Jun Clin Mol Hepatol Original Article BACKGROUND/AIMS: The treatment strategy for hepatitis C virus (HCV) has been changing rapidly since the introduction of direct-acting antivirals such as daclatasvir (DCV) and asunaprevir (ASV). We evaluated the efficacy and safety of DCV and ASV for HCV in real-life practice. METHODS: Patients were treated with 60 mg of DCV once daily plus 200 mg of ASV twice daily for 24 weeks, and followed for 12 weeks. The primary endpoint was a sustained virological response at 12 weeks after treatment (SVR(12)) and safety. RESULTS: This retrospective study included eight patients with chronic HCV genotype 1b infection. All of the enrolled patients were diagnosed with liver cirrhosis, and their mean age was 65.75 years. One patient was a nonresponder and two patients relapsed with previous pegylated interferon (PegIFN) and ribavirin (RBV) treatment. None of the patient showed NS5A mutation. An SVR(12) was achieved in 88% of cases by the DCV and ASV combination therapy. The serum transaminase level and the aspartate-aminotransferase-to-platelet ratio were improved after the treatment. DCV and ASV were well tolerated in most of the patients, with treatment discontinuation due to adverse events (elevated liver enzyme and decompensation) occurring in two patients. CONCLUSION: In this study, combination of DCV and ASV treatment achieved a high sustained virological response with few adverse events even in those with cirrhosis, advanced age, and nonresponse/relapse to previous interferon-based therapy. Close monitoring of safety issues may be necessary when treating chronic HCV patients receiving DCV and ASV, especially in older patient and those with cirrhosis. The Korean Association for the Study of the Liver 2016-06 2016-06-25 /pmc/articles/PMC4946403/ /pubmed/27377910 http://dx.doi.org/10.3350/cmh.2016.0020 Text en Copyright © 2016 by The Korean Association for the Study of the Liver This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Nam, Hee Chul
Lee, Hae Lim
Yang, Hyun
Song, Myeong Jun
Efficacy and safety of daclatasvir and asunaprevir for hepatitis C virus genotype 1b infection
title Efficacy and safety of daclatasvir and asunaprevir for hepatitis C virus genotype 1b infection
title_full Efficacy and safety of daclatasvir and asunaprevir for hepatitis C virus genotype 1b infection
title_fullStr Efficacy and safety of daclatasvir and asunaprevir for hepatitis C virus genotype 1b infection
title_full_unstemmed Efficacy and safety of daclatasvir and asunaprevir for hepatitis C virus genotype 1b infection
title_short Efficacy and safety of daclatasvir and asunaprevir for hepatitis C virus genotype 1b infection
title_sort efficacy and safety of daclatasvir and asunaprevir for hepatitis c virus genotype 1b infection
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946403/
https://www.ncbi.nlm.nih.gov/pubmed/27377910
http://dx.doi.org/10.3350/cmh.2016.0020
work_keys_str_mv AT namheechul efficacyandsafetyofdaclatasvirandasunaprevirforhepatitiscvirusgenotype1binfection
AT leehaelim efficacyandsafetyofdaclatasvirandasunaprevirforhepatitiscvirusgenotype1binfection
AT yanghyun efficacyandsafetyofdaclatasvirandasunaprevirforhepatitiscvirusgenotype1binfection
AT songmyeongjun efficacyandsafetyofdaclatasvirandasunaprevirforhepatitiscvirusgenotype1binfection