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Lowered Immune Cell Function in Liver Recipients Recovered From Posttransplant Lymphoproliferative Disease Who Developed Graft Tolerance

Tolerance after treatment and recovery from posttransplant lymphoproliferative disease (PTLD) have been described but little is known about the immunology. The objective of this study is to evaluate the immunity of pediatric recipients who recovered from PTLD. MATERIALS AND METHODS: Pediatric recipi...

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Autores principales: Chung, Patrick Ho Yu, Chan, See Ching, Chan, Kwong Leung, Chan, Yuk Sing, Kwok, Janette Siu Yin, Lo, Chung Mau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946509/
https://www.ncbi.nlm.nih.gov/pubmed/27500258
http://dx.doi.org/10.1097/TXD.0000000000000577
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author Chung, Patrick Ho Yu
Chan, See Ching
Chan, Kwong Leung
Chan, Yuk Sing
Kwok, Janette Siu Yin
Lo, Chung Mau
author_facet Chung, Patrick Ho Yu
Chan, See Ching
Chan, Kwong Leung
Chan, Yuk Sing
Kwok, Janette Siu Yin
Lo, Chung Mau
author_sort Chung, Patrick Ho Yu
collection PubMed
description Tolerance after treatment and recovery from posttransplant lymphoproliferative disease (PTLD) have been described but little is known about the immunology. The objective of this study is to evaluate the immunity of pediatric recipients who recovered from PTLD. MATERIALS AND METHODS: Pediatric recipients who recovered from PTLD after liver transplant and twice the number of recipients who never had PTLD were recruited. Their immune statuses were measured by ImmuKnow (measurement of adenosine 5-triphospate level produced CD4+ T helper cells), and the results were divided into 3 groups, “low” (≤225 ng/mL), “moderate” (226 to 524 ng/mL), and “high” (≥525 ng/mL). The results of both groups were compared and analyzed. RESULTS: Nine PTLD recipients and 20 non-PTLD recipients were recruited. There were no significant differences in terms of sex and age between the 2 groups. The majority of PTLD recipients (88.9%) had “low” immune status responses, and none of them had “high” responses. For non-PTLD recipients, more than half (55%) had “moderate” immune status responses. The median value of adenosine 5-triphospate levels was significantly lower in the PTLD group (119 ng/mL vs 380.5 ng/mL P = 0.014), and their trough immunosuppressant level was also lower (3.8 μg/L vs 7.7 μg/L; P = 0.004). None of the patients in either group had abnormal liver enzymes (aspartate aminotransferase/alanine aminotransferase) to suggest graft rejection. CONCLUSIONS: Patients who recovered from PTLD have a lower CD4 T-cell activity compared with those who have not suffered from PTLD. Under careful monitoring, their immunosuppressant levels can be kept at low levels to prevent recurrence of PTLD.
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spelling pubmed-49465092016-08-05 Lowered Immune Cell Function in Liver Recipients Recovered From Posttransplant Lymphoproliferative Disease Who Developed Graft Tolerance Chung, Patrick Ho Yu Chan, See Ching Chan, Kwong Leung Chan, Yuk Sing Kwok, Janette Siu Yin Lo, Chung Mau Transplant Direct Liver Transplantation Tolerance after treatment and recovery from posttransplant lymphoproliferative disease (PTLD) have been described but little is known about the immunology. The objective of this study is to evaluate the immunity of pediatric recipients who recovered from PTLD. MATERIALS AND METHODS: Pediatric recipients who recovered from PTLD after liver transplant and twice the number of recipients who never had PTLD were recruited. Their immune statuses were measured by ImmuKnow (measurement of adenosine 5-triphospate level produced CD4+ T helper cells), and the results were divided into 3 groups, “low” (≤225 ng/mL), “moderate” (226 to 524 ng/mL), and “high” (≥525 ng/mL). The results of both groups were compared and analyzed. RESULTS: Nine PTLD recipients and 20 non-PTLD recipients were recruited. There were no significant differences in terms of sex and age between the 2 groups. The majority of PTLD recipients (88.9%) had “low” immune status responses, and none of them had “high” responses. For non-PTLD recipients, more than half (55%) had “moderate” immune status responses. The median value of adenosine 5-triphospate levels was significantly lower in the PTLD group (119 ng/mL vs 380.5 ng/mL P = 0.014), and their trough immunosuppressant level was also lower (3.8 μg/L vs 7.7 μg/L; P = 0.004). None of the patients in either group had abnormal liver enzymes (aspartate aminotransferase/alanine aminotransferase) to suggest graft rejection. CONCLUSIONS: Patients who recovered from PTLD have a lower CD4 T-cell activity compared with those who have not suffered from PTLD. Under careful monitoring, their immunosuppressant levels can be kept at low levels to prevent recurrence of PTLD. Lippincott Williams & Wilkins 2016-02-17 /pmc/articles/PMC4946509/ /pubmed/27500258 http://dx.doi.org/10.1097/TXD.0000000000000577 Text en Copyright © 2016 The Authors. Transplantation Direct. Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Liver Transplantation
Chung, Patrick Ho Yu
Chan, See Ching
Chan, Kwong Leung
Chan, Yuk Sing
Kwok, Janette Siu Yin
Lo, Chung Mau
Lowered Immune Cell Function in Liver Recipients Recovered From Posttransplant Lymphoproliferative Disease Who Developed Graft Tolerance
title Lowered Immune Cell Function in Liver Recipients Recovered From Posttransplant Lymphoproliferative Disease Who Developed Graft Tolerance
title_full Lowered Immune Cell Function in Liver Recipients Recovered From Posttransplant Lymphoproliferative Disease Who Developed Graft Tolerance
title_fullStr Lowered Immune Cell Function in Liver Recipients Recovered From Posttransplant Lymphoproliferative Disease Who Developed Graft Tolerance
title_full_unstemmed Lowered Immune Cell Function in Liver Recipients Recovered From Posttransplant Lymphoproliferative Disease Who Developed Graft Tolerance
title_short Lowered Immune Cell Function in Liver Recipients Recovered From Posttransplant Lymphoproliferative Disease Who Developed Graft Tolerance
title_sort lowered immune cell function in liver recipients recovered from posttransplant lymphoproliferative disease who developed graft tolerance
topic Liver Transplantation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946509/
https://www.ncbi.nlm.nih.gov/pubmed/27500258
http://dx.doi.org/10.1097/TXD.0000000000000577
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