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The Lowest Prevalence of Cholelithiasis in the Americas - An Autopsy-based Study

OBJECTIVES: This study used autopsy to evaluate the prevalence of cholelithiasis and its associated risk factors in a population of healthy, young subjects who suffered a violent or natural death. METHODS: This study is a prospective evaluation of autopsies of 446 individuals from 2011 to 2013 in Br...

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Autores principales: Asperti, André Marangoni, Reis, Paulo, Diniz, Marcio Augusto, Pinto, Mariana Dourado, da Silva, Edinésio Carlos, da Silva, Danilo Felipe Dias, D’Albuquerque, Luiz Augusto Carneiro, Andraus, Wellington
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946535/
https://www.ncbi.nlm.nih.gov/pubmed/27464291
http://dx.doi.org/10.6061/clinics/2016(07)02
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author Asperti, André Marangoni
Reis, Paulo
Diniz, Marcio Augusto
Pinto, Mariana Dourado
da Silva, Edinésio Carlos
da Silva, Danilo Felipe Dias
D’Albuquerque, Luiz Augusto Carneiro
Andraus, Wellington
author_facet Asperti, André Marangoni
Reis, Paulo
Diniz, Marcio Augusto
Pinto, Mariana Dourado
da Silva, Edinésio Carlos
da Silva, Danilo Felipe Dias
D’Albuquerque, Luiz Augusto Carneiro
Andraus, Wellington
author_sort Asperti, André Marangoni
collection PubMed
description OBJECTIVES: This study used autopsy to evaluate the prevalence of cholelithiasis and its associated risk factors in a population of healthy, young subjects who suffered a violent or natural death. METHODS: This study is a prospective evaluation of autopsies of 446 individuals from 2011 to 2013 in Brazil. Of that sample, 330 (74%) subjects died from violent deaths and 116 (26%) died naturally. The presence of biliary calculi, previous cholecystectomy, gender, age, ethnicity, body mass index (BMI) and alcohol use were evaluated. RESULTS: In the natural death group, 6.9% (95% CI 3.39 to 13.28) (3.08% of the male subjects and 11.76% of the female subjects) exhibited evidence of gallbladder disease. In the violent death group, only 2.12% (95% CI 0.96 to 4.43) (2.17% of the male subjects and 1.85% of the female subjects) of the subjects exhibited evidence of gallbladder disease. Age was correlated with the prevalence of gallbladder disease, but BMI was correlated with only gallbladder disease in the natural death group. CONCLUSIONS: This population has the lowest prevalence of cholelithiasis in the Americas. Dietary habits, physical activity, ethnicity, alcohol consumption and genetic factors may be responsible for this low prevalence.
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spelling pubmed-49465352016-08-17 The Lowest Prevalence of Cholelithiasis in the Americas - An Autopsy-based Study Asperti, André Marangoni Reis, Paulo Diniz, Marcio Augusto Pinto, Mariana Dourado da Silva, Edinésio Carlos da Silva, Danilo Felipe Dias D’Albuquerque, Luiz Augusto Carneiro Andraus, Wellington Clinics (Sao Paulo) Clinical Science OBJECTIVES: This study used autopsy to evaluate the prevalence of cholelithiasis and its associated risk factors in a population of healthy, young subjects who suffered a violent or natural death. METHODS: This study is a prospective evaluation of autopsies of 446 individuals from 2011 to 2013 in Brazil. Of that sample, 330 (74%) subjects died from violent deaths and 116 (26%) died naturally. The presence of biliary calculi, previous cholecystectomy, gender, age, ethnicity, body mass index (BMI) and alcohol use were evaluated. RESULTS: In the natural death group, 6.9% (95% CI 3.39 to 13.28) (3.08% of the male subjects and 11.76% of the female subjects) exhibited evidence of gallbladder disease. In the violent death group, only 2.12% (95% CI 0.96 to 4.43) (2.17% of the male subjects and 1.85% of the female subjects) of the subjects exhibited evidence of gallbladder disease. Age was correlated with the prevalence of gallbladder disease, but BMI was correlated with only gallbladder disease in the natural death group. CONCLUSIONS: This population has the lowest prevalence of cholelithiasis in the Americas. Dietary habits, physical activity, ethnicity, alcohol consumption and genetic factors may be responsible for this low prevalence. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2016-07 2016-07 /pmc/articles/PMC4946535/ /pubmed/27464291 http://dx.doi.org/10.6061/clinics/2016(07)02 Text en Copyright © 2016 CLINICS http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Science
Asperti, André Marangoni
Reis, Paulo
Diniz, Marcio Augusto
Pinto, Mariana Dourado
da Silva, Edinésio Carlos
da Silva, Danilo Felipe Dias
D’Albuquerque, Luiz Augusto Carneiro
Andraus, Wellington
The Lowest Prevalence of Cholelithiasis in the Americas - An Autopsy-based Study
title The Lowest Prevalence of Cholelithiasis in the Americas - An Autopsy-based Study
title_full The Lowest Prevalence of Cholelithiasis in the Americas - An Autopsy-based Study
title_fullStr The Lowest Prevalence of Cholelithiasis in the Americas - An Autopsy-based Study
title_full_unstemmed The Lowest Prevalence of Cholelithiasis in the Americas - An Autopsy-based Study
title_short The Lowest Prevalence of Cholelithiasis in the Americas - An Autopsy-based Study
title_sort lowest prevalence of cholelithiasis in the americas - an autopsy-based study
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946535/
https://www.ncbi.nlm.nih.gov/pubmed/27464291
http://dx.doi.org/10.6061/clinics/2016(07)02
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