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The Lowest Prevalence of Cholelithiasis in the Americas - An Autopsy-based Study
OBJECTIVES: This study used autopsy to evaluate the prevalence of cholelithiasis and its associated risk factors in a population of healthy, young subjects who suffered a violent or natural death. METHODS: This study is a prospective evaluation of autopsies of 446 individuals from 2011 to 2013 in Br...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946535/ https://www.ncbi.nlm.nih.gov/pubmed/27464291 http://dx.doi.org/10.6061/clinics/2016(07)02 |
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author | Asperti, André Marangoni Reis, Paulo Diniz, Marcio Augusto Pinto, Mariana Dourado da Silva, Edinésio Carlos da Silva, Danilo Felipe Dias D’Albuquerque, Luiz Augusto Carneiro Andraus, Wellington |
author_facet | Asperti, André Marangoni Reis, Paulo Diniz, Marcio Augusto Pinto, Mariana Dourado da Silva, Edinésio Carlos da Silva, Danilo Felipe Dias D’Albuquerque, Luiz Augusto Carneiro Andraus, Wellington |
author_sort | Asperti, André Marangoni |
collection | PubMed |
description | OBJECTIVES: This study used autopsy to evaluate the prevalence of cholelithiasis and its associated risk factors in a population of healthy, young subjects who suffered a violent or natural death. METHODS: This study is a prospective evaluation of autopsies of 446 individuals from 2011 to 2013 in Brazil. Of that sample, 330 (74%) subjects died from violent deaths and 116 (26%) died naturally. The presence of biliary calculi, previous cholecystectomy, gender, age, ethnicity, body mass index (BMI) and alcohol use were evaluated. RESULTS: In the natural death group, 6.9% (95% CI 3.39 to 13.28) (3.08% of the male subjects and 11.76% of the female subjects) exhibited evidence of gallbladder disease. In the violent death group, only 2.12% (95% CI 0.96 to 4.43) (2.17% of the male subjects and 1.85% of the female subjects) of the subjects exhibited evidence of gallbladder disease. Age was correlated with the prevalence of gallbladder disease, but BMI was correlated with only gallbladder disease in the natural death group. CONCLUSIONS: This population has the lowest prevalence of cholelithiasis in the Americas. Dietary habits, physical activity, ethnicity, alcohol consumption and genetic factors may be responsible for this low prevalence. |
format | Online Article Text |
id | pubmed-4946535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-49465352016-08-17 The Lowest Prevalence of Cholelithiasis in the Americas - An Autopsy-based Study Asperti, André Marangoni Reis, Paulo Diniz, Marcio Augusto Pinto, Mariana Dourado da Silva, Edinésio Carlos da Silva, Danilo Felipe Dias D’Albuquerque, Luiz Augusto Carneiro Andraus, Wellington Clinics (Sao Paulo) Clinical Science OBJECTIVES: This study used autopsy to evaluate the prevalence of cholelithiasis and its associated risk factors in a population of healthy, young subjects who suffered a violent or natural death. METHODS: This study is a prospective evaluation of autopsies of 446 individuals from 2011 to 2013 in Brazil. Of that sample, 330 (74%) subjects died from violent deaths and 116 (26%) died naturally. The presence of biliary calculi, previous cholecystectomy, gender, age, ethnicity, body mass index (BMI) and alcohol use were evaluated. RESULTS: In the natural death group, 6.9% (95% CI 3.39 to 13.28) (3.08% of the male subjects and 11.76% of the female subjects) exhibited evidence of gallbladder disease. In the violent death group, only 2.12% (95% CI 0.96 to 4.43) (2.17% of the male subjects and 1.85% of the female subjects) of the subjects exhibited evidence of gallbladder disease. Age was correlated with the prevalence of gallbladder disease, but BMI was correlated with only gallbladder disease in the natural death group. CONCLUSIONS: This population has the lowest prevalence of cholelithiasis in the Americas. Dietary habits, physical activity, ethnicity, alcohol consumption and genetic factors may be responsible for this low prevalence. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2016-07 2016-07 /pmc/articles/PMC4946535/ /pubmed/27464291 http://dx.doi.org/10.6061/clinics/2016(07)02 Text en Copyright © 2016 CLINICS http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Science Asperti, André Marangoni Reis, Paulo Diniz, Marcio Augusto Pinto, Mariana Dourado da Silva, Edinésio Carlos da Silva, Danilo Felipe Dias D’Albuquerque, Luiz Augusto Carneiro Andraus, Wellington The Lowest Prevalence of Cholelithiasis in the Americas - An Autopsy-based Study |
title | The Lowest Prevalence of Cholelithiasis in the Americas - An Autopsy-based Study |
title_full | The Lowest Prevalence of Cholelithiasis in the Americas - An Autopsy-based Study |
title_fullStr | The Lowest Prevalence of Cholelithiasis in the Americas - An Autopsy-based Study |
title_full_unstemmed | The Lowest Prevalence of Cholelithiasis in the Americas - An Autopsy-based Study |
title_short | The Lowest Prevalence of Cholelithiasis in the Americas - An Autopsy-based Study |
title_sort | lowest prevalence of cholelithiasis in the americas - an autopsy-based study |
topic | Clinical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946535/ https://www.ncbi.nlm.nih.gov/pubmed/27464291 http://dx.doi.org/10.6061/clinics/2016(07)02 |
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