Cargando…

Combined inhibition of EZH2 and histone deacetylases as a potential epigenetic therapy for non‐small‐cell lung cancer cells

Recent discoveries have revealed that human cancer involves aberrant epigenetic alterations. We and others have previously shown that the histone methyltransferase EZH2, the catalytic subunit of polycomb repressive complex 2 (PRC2), is frequently overexpressed in non‐small‐cell lung cancer (NSCLC) a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Takashina, Taichi, Kinoshita, Ichiro, Kikuchi, Junko, Shimizu, Yasushi, Sakakibara‐Konishi, Jun, Oizumi, Satoshi, Nishimura, Masaharu, Dosaka‐Akita, Hirotoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946723/ https://www.ncbi.nlm.nih.gov/pubmed/27116120 http://dx.doi.org/10.1111/cas.12957

Ejemplares similares

Expression of Bim, Noxa, and Puma in non-small cell lung cancer
por: Sakakibara-Konishi, Jun, et al.
Publicado: (2012)

Numb has distinct function in lung adenocarcinoma and squamous cell carcinoma
por: Kikuchi, Hajime, et al.
Publicado: (2018)

Crystalline silica-exposed human lung epithelial cells presented enhanced anchorage-independent growth with upregulated expression of BRD4 and EZH2 in autocrine and paracrine manners
por: Katabami, Motoo, et al.
Publicado: (2023)

DLL3 regulates the migration and invasion of small cell lung cancer by modulating Snail
por: Furuta, Megumi, et al.
Publicado: (2019)

Simultaneous blockade of AP-1 and phosphatidylinositol 3-kinase pathway in non-small cell lung cancer cells
por: Kikuchi, J, et al.
Publicado: (2008)

Role of targeted therapy in metastatic colorectal cancer
por: Ohhara, Yoshihito, et al.
Publicado: (2016)

EGFR inhibition in EGFR‐mutant lung cancer cells perturbs innate immune signaling pathways in the tumor microenvironment
por: Shiiya, Akihiko, et al.
Publicado: (2022)

Overactivation of histone deacetylases and EZH2 in Wilms tumorigenesis
por: Chen, Chao-Hui, et al.
Publicado: (2022)

Clinical benefit of readministration of gefitinib for initial gefitinib-responders with non-small cell lung cancer
por: Yokouchi, Hiroshi, et al.
Publicado: (2007)

Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors
por: Takeda, Kayoko, et al.
Publicado: (2008)

Growth inhibition of non-small cell lung cancer cells by AP-1 blockade using a cJun dominant-negative mutant
por: Shimizu, Y, et al.
Publicado: (2008)

Autophagy-dependent regulation of tumor metastasis by myeloid cells
por: Jinushi, Masahisa, et al.
Publicado: (2017)

A Case of High-Grade Neuroendocrine Carcinoma That Improved with Bevacizumab plus Modified FOLFOX6 as the Fourth-Line Chemotherapy
por: Takeuchi, Satoshi, et al.
Publicado: (2011)

Low expression levels of microRNA-124-5p correlated with poor prognosis in colorectal cancer via targeting of SMC4
por: Jinushi, Takafumi, et al.
Publicado: (2014)

Expression of Notch1 and Numb in small cell lung cancer
por: Kikuchi, Hajime, et al.
Publicado: (2017)

First-line osimertinib in elderly patients with epidermal growth factor receptor-mutated advanced non-small cell lung cancer: a retrospective multicenter study (HOT2002)
por: Yamamoto, Gaku, et al.
Publicado: (2021)

Expression of Karyopherin Alpha 2 and Karyopherin Beta 1 Correlate with Poor Prognosis in Gastric Cancer
por: Ohhara, Yoshihito, et al.
Publicado: (2022)

Novel signaling collaboration between TGF-β and adaptor protein Crk facilitates EMT in human lung cancer
por: Elmansuri, Aiman Z., et al.
Publicado: (2016)

Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma
por: Phimmachanh, Monica, et al.
Publicado: (2020)

Histone deacetylases in RA: epigenetics and epiphenomena
por: Grabiec, Aleksander M, et al.
Publicado: (2010)

Histone Deacetylases and Their Inhibitors in Cancer Epigenetics
por: Hassell, Kelly N.
Publicado: (2019)

γ-Secretase inhibitor enhances antitumour effect of radiation in Notch-expressing lung cancer
por: Mizugaki, H, et al.
Publicado: (2012)

Detection of somatic TP53 mutation in surgically resected small-cell lung cancer by targeted exome sequencing: association with longer relapse-free survival
por: Yokouchi, Hiroshi, et al.
Publicado: (2020)

Histone deacetylase 9 regulates breast cancer cell proliferation and the response to histone deacetylase inhibitors
por: Lapierre, Marion, et al.
Publicado: (2016)

Histone Deacetylase Inhibitors, Intrinsic and Extrinsic Apoptotic Pathways, and Epigenetic Alterations of Histone Deacetylases (HDACs) in Hepatocellular Carcinoma
por: Sanaei, Masumeh, et al.
Publicado: (2021)

Early prediction of lenvatinib treatment efficacy by using (18)F-FDG PET/CT in patients with unresectable or advanced thyroid carcinoma that is refractory to radioiodine treatment: a protocol for a non-randomized single-arm multicenter observational study
por: Takeuchi, Satoshi, et al.
Publicado: (2018)

Prognostic significance of OX40(+) lymphocytes in tumor stroma of surgically resected small-cell lung cancer
por: Yokouchi, Hiroshi, et al.
Publicado: (2021)

Beyond Histone and Deacetylase: An Overview of Cytoplasmic Histone Deacetylases and Their Nonhistone Substrates
por: Yao, Ya-Li, et al.
Publicado: (2011)

Survey of the management of chemotherapy-induced peripheral neuropathy in Japan: Japanese Society of Medical Oncology
por: Hirayama, Yasuo, et al.
Publicado: (2016)

Role of Histone Deacetylases in T-Cell Development and Function
por: Pieniawska, Monika, et al.
Publicado: (2022)

Statins and Histone Deacetylase Inhibitors Affect Lamin A/C – Histone Deacetylase 2 Interaction in Human Cells
por: Mattioli, Elisabetta, et al.
Publicado: (2019)

Histone Deacetylase Expressions in Hepatocellular Carcinoma and Functional Effects of Histone Deacetylase Inhibitors on Liver Cancer Cells In Vitro
por: Freese, Kim, et al.
Publicado: (2019)

Epigenetic Targeting of Histone Deacetylases in Diagnostics and Treatment of Depression
por: Park, Hyun-Sun, et al.
Publicado: (2021)

Histone Deacetylases as Epigenetic Targets for Treating Parkinson’s Disease
por: Li, Yan, et al.
Publicado: (2022)

Patho-epigenetics: histone deacetylases as targets of pathogens and therapeutics
por: Schator, Daniel, et al.
Publicado: (2021)

Early prediction of treatment outcome for lenvatinib using (18)F-FDG PET/CT in patients with unresectable or advanced thyroid carcinoma refractory to radioiodine treatment: a prospective, multicentre, non-randomised study
por: Takeuchi, Satoshi, et al.
Publicado: (2023)

Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy
por: Haery, Leila, et al.
Publicado: (2015)

Histone Deacetylases and Histone Deacetylase Inhibitors: Molecular Mechanisms of Action in Various Cancers
por: Sanaei, Masumeh, et al.
Publicado: (2019)

Successful Application of Edoxaban in the Treatment of Venous Thromboembolism Recurrence in a Patient with Non-small Cell Lung Cancer after Tumor Shrinkage
por: Shoji, Tetsuaki, et al.
Publicado: (2018)

Real‐world data on the efficacy and safety of immune‐checkpoint inhibitors in elderly patients with non‐small cell lung cancer
por: Morinaga, Daisuke, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_smpm7icji7n2efdn6kv44enhip