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Treating hepatitis C virus in children: time for a new paradigm

Hepatitis C virus infection is a leading cause of liver-related morbidity and mortality. In the paediatric population, HCV infection is underdiagnosed and undertreated in the absence of robust screening policies worldwide, and a lack of tolerable, effective treatment. The recent advances in HCV drug...

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Autores principales: Thorne, Claire, Indolfi, Giuseppe, Turkova, Anna, Giaquinto, Carlo, Nastouli, Eleni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mediscript Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946741/
https://www.ncbi.nlm.nih.gov/pubmed/27482412
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author Thorne, Claire
Indolfi, Giuseppe
Turkova, Anna
Giaquinto, Carlo
Nastouli, Eleni
author_facet Thorne, Claire
Indolfi, Giuseppe
Turkova, Anna
Giaquinto, Carlo
Nastouli, Eleni
author_sort Thorne, Claire
collection PubMed
description Hepatitis C virus infection is a leading cause of liver-related morbidity and mortality. In the paediatric population, HCV infection is underdiagnosed and undertreated in the absence of robust screening policies worldwide, and a lack of tolerable, effective treatment. The recent advances in HCV drug development allow for optimism, a change in outcomes for the millions of children infected with this virus and a unique opportunity for strategies aiming at HCV eradication. The rapid development of the new compounds has been followed by a welcome shift in the regulatory processes; however, strategies aiming at improving diagnosis, selecting the best combinations and addressing mother-to-child transmission issues are required for the new therapeutic agents to be introduced safely and effectively in the paediatric population and to contribute to the goal of virus eradication.
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spelling pubmed-49467412016-08-01 Treating hepatitis C virus in children: time for a new paradigm Thorne, Claire Indolfi, Giuseppe Turkova, Anna Giaquinto, Carlo Nastouli, Eleni J Virus Erad Viewpoint Hepatitis C virus infection is a leading cause of liver-related morbidity and mortality. In the paediatric population, HCV infection is underdiagnosed and undertreated in the absence of robust screening policies worldwide, and a lack of tolerable, effective treatment. The recent advances in HCV drug development allow for optimism, a change in outcomes for the millions of children infected with this virus and a unique opportunity for strategies aiming at HCV eradication. The rapid development of the new compounds has been followed by a welcome shift in the regulatory processes; however, strategies aiming at improving diagnosis, selecting the best combinations and addressing mother-to-child transmission issues are required for the new therapeutic agents to be introduced safely and effectively in the paediatric population and to contribute to the goal of virus eradication. Mediscript Ltd 2015-07-01 /pmc/articles/PMC4946741/ /pubmed/27482412 Text en © 2015 The Authors. Journal of Virus Eradication published by Mediscript Ltd http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article published under the terms of a Creative Commons License.
spellingShingle Viewpoint
Thorne, Claire
Indolfi, Giuseppe
Turkova, Anna
Giaquinto, Carlo
Nastouli, Eleni
Treating hepatitis C virus in children: time for a new paradigm
title Treating hepatitis C virus in children: time for a new paradigm
title_full Treating hepatitis C virus in children: time for a new paradigm
title_fullStr Treating hepatitis C virus in children: time for a new paradigm
title_full_unstemmed Treating hepatitis C virus in children: time for a new paradigm
title_short Treating hepatitis C virus in children: time for a new paradigm
title_sort treating hepatitis c virus in children: time for a new paradigm
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946741/
https://www.ncbi.nlm.nih.gov/pubmed/27482412
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