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Treating hepatitis C virus in children: time for a new paradigm
Hepatitis C virus infection is a leading cause of liver-related morbidity and mortality. In the paediatric population, HCV infection is underdiagnosed and undertreated in the absence of robust screening policies worldwide, and a lack of tolerable, effective treatment. The recent advances in HCV drug...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mediscript Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946741/ https://www.ncbi.nlm.nih.gov/pubmed/27482412 |
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author | Thorne, Claire Indolfi, Giuseppe Turkova, Anna Giaquinto, Carlo Nastouli, Eleni |
author_facet | Thorne, Claire Indolfi, Giuseppe Turkova, Anna Giaquinto, Carlo Nastouli, Eleni |
author_sort | Thorne, Claire |
collection | PubMed |
description | Hepatitis C virus infection is a leading cause of liver-related morbidity and mortality. In the paediatric population, HCV infection is underdiagnosed and undertreated in the absence of robust screening policies worldwide, and a lack of tolerable, effective treatment. The recent advances in HCV drug development allow for optimism, a change in outcomes for the millions of children infected with this virus and a unique opportunity for strategies aiming at HCV eradication. The rapid development of the new compounds has been followed by a welcome shift in the regulatory processes; however, strategies aiming at improving diagnosis, selecting the best combinations and addressing mother-to-child transmission issues are required for the new therapeutic agents to be introduced safely and effectively in the paediatric population and to contribute to the goal of virus eradication. |
format | Online Article Text |
id | pubmed-4946741 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Mediscript Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-49467412016-08-01 Treating hepatitis C virus in children: time for a new paradigm Thorne, Claire Indolfi, Giuseppe Turkova, Anna Giaquinto, Carlo Nastouli, Eleni J Virus Erad Viewpoint Hepatitis C virus infection is a leading cause of liver-related morbidity and mortality. In the paediatric population, HCV infection is underdiagnosed and undertreated in the absence of robust screening policies worldwide, and a lack of tolerable, effective treatment. The recent advances in HCV drug development allow for optimism, a change in outcomes for the millions of children infected with this virus and a unique opportunity for strategies aiming at HCV eradication. The rapid development of the new compounds has been followed by a welcome shift in the regulatory processes; however, strategies aiming at improving diagnosis, selecting the best combinations and addressing mother-to-child transmission issues are required for the new therapeutic agents to be introduced safely and effectively in the paediatric population and to contribute to the goal of virus eradication. Mediscript Ltd 2015-07-01 /pmc/articles/PMC4946741/ /pubmed/27482412 Text en © 2015 The Authors. Journal of Virus Eradication published by Mediscript Ltd http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article published under the terms of a Creative Commons License. |
spellingShingle | Viewpoint Thorne, Claire Indolfi, Giuseppe Turkova, Anna Giaquinto, Carlo Nastouli, Eleni Treating hepatitis C virus in children: time for a new paradigm |
title | Treating hepatitis C virus in children: time for a new paradigm |
title_full | Treating hepatitis C virus in children: time for a new paradigm |
title_fullStr | Treating hepatitis C virus in children: time for a new paradigm |
title_full_unstemmed | Treating hepatitis C virus in children: time for a new paradigm |
title_short | Treating hepatitis C virus in children: time for a new paradigm |
title_sort | treating hepatitis c virus in children: time for a new paradigm |
topic | Viewpoint |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946741/ https://www.ncbi.nlm.nih.gov/pubmed/27482412 |
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