53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis

Mitosis occurs efficiently, but when it is disturbed or delayed, p53-dependent cell death or senescence is often triggered after mitotic exit. To characterize this process, we conducted CRISPR-mediated loss-of-function screens using a cell-based assay in which mitosis is consistently disturbed by ce...

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Detalles Bibliográficos
Autores principales: Fong, Chii Shyang, Mazo, Gregory, Das, Tuhin, Goodman, Joshua, Kim, Minhee, O'Rourke, Brian P, Izquierdo, Denisse, Tsou, Meng-Fu Bryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946878/
https://www.ncbi.nlm.nih.gov/pubmed/27371829
http://dx.doi.org/10.7554/eLife.16270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946878/
https://www.ncbi.nlm.nih.gov/pubmed/27371829
http://dx.doi.org/10.7554/eLife.16270

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