Diagnostic potential of tumor DNA from ovarian cyst fluid

We determined whether the mutations found in ovarian cancers could be identified in the patients' ovarian cyst fluids. Tumor-specific mutations were detectable in the cyst fluids of 19 of 23 (83%) borderline tumors, 10 of 13 (77%) type I cancers, and 18 of 18 (100%) type II cancers. In contrast...

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Autores principales: Wang, Yuxuan, Sundfeldt, Karin, Mateoiu, Constantina, Shih, Ie-Ming, Kurman, Robert J, Schaefer, Joy, Silliman, Natalie, Kinde, Isaac, Springer, Simeon, Foote, Michael, Kristjansdottir, Björg, James, Nathan, Kinzler, Kenneth W, Papadopoulos, Nickolas, Diaz, Luis A, Vogelstein, Bert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946896/
https://www.ncbi.nlm.nih.gov/pubmed/27421040
http://dx.doi.org/10.7554/eLife.15175
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author Wang, Yuxuan
Sundfeldt, Karin
Mateoiu, Constantina
Shih, Ie-Ming
Kurman, Robert J
Schaefer, Joy
Silliman, Natalie
Kinde, Isaac
Springer, Simeon
Foote, Michael
Kristjansdottir, Björg
James, Nathan
Kinzler, Kenneth W
Papadopoulos, Nickolas
Diaz, Luis A
Vogelstein, Bert
author_facet Wang, Yuxuan
Sundfeldt, Karin
Mateoiu, Constantina
Shih, Ie-Ming
Kurman, Robert J
Schaefer, Joy
Silliman, Natalie
Kinde, Isaac
Springer, Simeon
Foote, Michael
Kristjansdottir, Björg
James, Nathan
Kinzler, Kenneth W
Papadopoulos, Nickolas
Diaz, Luis A
Vogelstein, Bert
author_sort Wang, Yuxuan
collection PubMed
description We determined whether the mutations found in ovarian cancers could be identified in the patients' ovarian cyst fluids. Tumor-specific mutations were detectable in the cyst fluids of 19 of 23 (83%) borderline tumors, 10 of 13 (77%) type I cancers, and 18 of 18 (100%) type II cancers. In contrast, no mutations were found in the cyst fluids of 18 patients with benign tumors or non-neoplastic cysts. Though large, prospective studies are needed to demonstrate the safety and clinical utility of this approach, our results suggest that the genetic evaluation of cyst fluids might be able to inform the management of the large number of women with these lesions. DOI: http://dx.doi.org/10.7554/eLife.15175.001
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spelling pubmed-49468962016-07-19 Diagnostic potential of tumor DNA from ovarian cyst fluid Wang, Yuxuan Sundfeldt, Karin Mateoiu, Constantina Shih, Ie-Ming Kurman, Robert J Schaefer, Joy Silliman, Natalie Kinde, Isaac Springer, Simeon Foote, Michael Kristjansdottir, Björg James, Nathan Kinzler, Kenneth W Papadopoulos, Nickolas Diaz, Luis A Vogelstein, Bert eLife Cancer Biology We determined whether the mutations found in ovarian cancers could be identified in the patients' ovarian cyst fluids. Tumor-specific mutations were detectable in the cyst fluids of 19 of 23 (83%) borderline tumors, 10 of 13 (77%) type I cancers, and 18 of 18 (100%) type II cancers. In contrast, no mutations were found in the cyst fluids of 18 patients with benign tumors or non-neoplastic cysts. Though large, prospective studies are needed to demonstrate the safety and clinical utility of this approach, our results suggest that the genetic evaluation of cyst fluids might be able to inform the management of the large number of women with these lesions. DOI: http://dx.doi.org/10.7554/eLife.15175.001 eLife Sciences Publications, Ltd 2016-07-15 /pmc/articles/PMC4946896/ /pubmed/27421040 http://dx.doi.org/10.7554/eLife.15175 Text en © 2016, Wang et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Cancer Biology
Wang, Yuxuan
Sundfeldt, Karin
Mateoiu, Constantina
Shih, Ie-Ming
Kurman, Robert J
Schaefer, Joy
Silliman, Natalie
Kinde, Isaac
Springer, Simeon
Foote, Michael
Kristjansdottir, Björg
James, Nathan
Kinzler, Kenneth W
Papadopoulos, Nickolas
Diaz, Luis A
Vogelstein, Bert
Diagnostic potential of tumor DNA from ovarian cyst fluid
title Diagnostic potential of tumor DNA from ovarian cyst fluid
title_full Diagnostic potential of tumor DNA from ovarian cyst fluid
title_fullStr Diagnostic potential of tumor DNA from ovarian cyst fluid
title_full_unstemmed Diagnostic potential of tumor DNA from ovarian cyst fluid
title_short Diagnostic potential of tumor DNA from ovarian cyst fluid
title_sort diagnostic potential of tumor dna from ovarian cyst fluid
topic Cancer Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946896/
https://www.ncbi.nlm.nih.gov/pubmed/27421040
http://dx.doi.org/10.7554/eLife.15175
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