Cargando…

CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of Syntaxins

Axon injury triggers dramatic changes in gene expression. While transcriptional regulation of injury-induced gene expression is widely studied, less is known about the roles of RNA binding proteins (RBPs) in post-transcriptional regulation during axon regeneration. In C. elegans the CELF (CUGBP and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Lizhen, Liu, Zhijie, Zhou, Bing, Wei, Chaoliang, Zhou, Yu, Rosenfeld, Michael G, Fu, Xiang-Dong, Chisholm, Andrew D, Jin, Yishi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946901/ https://www.ncbi.nlm.nih.gov/pubmed/27253061 http://dx.doi.org/10.7554/eLife.16072

Ejemplares similares

CELF2 regulates the species-specific alternative splicing of TREM2
por: Yanaizu, Motoaki, et al.
Publicado: (2020)

Repression of nuclear CELF activity can rescue CELF-regulated alternative splicing defects in skeletal muscle models of myotonic dystrophy
por: Berger, Dara S., et al.
Publicado: (2012)

Unraveling the mechanisms of synapse formation and axon regeneration: the awesome power of C. elegans genetics
por: YiShi, JIN
Publicado: (2015)

A Select Subset of Electron Transport Chain Genes Associated with Optic Atrophy Link Mitochondria to Axon Regeneration in Caenorhabditis elegans
por: Knowlton, Wendy M., et al.
Publicado: (2017)

Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans
por: Kuroyanagi, Hidehito, et al.
Publicado: (2013)

Identification of CELF splicing activation and repression domains in vivo
por: Han, Jin, et al.
Publicado: (2005)

MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1
por: Kino, Yoshihiro, et al.
Publicado: (2009)

Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD(+) in axon regeneration
por: Kim, Kyung Won, et al.
Publicado: (2018)

Regulation of Microtubule Dynamics in Axon Regeneration: Insights from C. elegans
por: Tang, Ngang Heok, et al.
Publicado: (2016)

Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians
por: Solana, Jordi, et al.
Publicado: (2016)

Syntaxin 5 Is Required for Copper Homeostasis in Drosophila and Mammals
por: Norgate, Melanie, et al.
Publicado: (2010)

Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase
por: Chen, Lizhen, et al.
Publicado: (2015)

Distribution of alternative untranslated regions within the mRNA of the CELF1 splicing factor affects its expression
por: Kajdasz, Arkadiusz, et al.
Publicado: (2022)

Regrowing axons with alternative splicing
por: Kramer, Nicholas J, et al.
Publicado: (2016)

Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins
por: Wang, Eric T., et al.
Publicado: (2015)

Connections between Alternative Transcription and Alternative Splicing in Mammals
por: Shabalina, Svetlana A., et al.
Publicado: (2010)

Axon Injury-Induced Autophagy Activation Is Impaired in a C. elegans Model of Tauopathy
por: Ko, Su-Hyuk, et al.
Publicado: (2020)

rbSec1A and B colocalize with syntaxin 1 and SNAP-25 throughout the axon, but are not in a stable complex with syntaxin
Publicado: (1995)

Ancient antagonism between CELF and RBFOX families tunes mRNA splicing outcomes
por: Gazzara, Matthew R., et al.
Publicado: (2017)

DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons
por: Noblett, Nathaniel, et al.
Publicado: (2019)

Regulation of neuronal axon specification by glia-neuron gap junctions in C. elegans
por: Meng, Lingfeng, et al.
Publicado: (2016)

Deletion of Krüppel-like factor-4 promotes axonal regeneration in mammals
por: Xu, Jin-Hui, et al.
Publicado: (2020)

Regulation of axon regeneration by the RNA repair/splicing pathway
por: Song, Yuanquan, et al.
Publicado: (2015)

Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans
por: Tien, Chi-Wei, et al.
Publicado: (2020)

Functional Dissection of C. elegans bZip-Protein CEBP-1 Reveals Novel Structural Motifs Required for Axon Regeneration and Nuclear Import
por: Malinow, Rose Aria, et al.
Publicado: (2019)

The Predicted RNA-Binding Protein ETR-1/CELF1 Acts in Muscles To Regulate Neuroblast Migration in Caenorhabditis elegans
por: Ochs, Matthew E., et al.
Publicado: (2020)

N6-methyladenosine-mediated CELF2 regulates CD44 alternative splicing affecting tumorigenesis via ERAD pathway in pancreatic cancer
por: Lai, Shihui, et al.
Publicado: (2022)

Position-dependent activity of CELF2 in the regulation of splicing and implications for signal-responsive regulation in T cells
por: Ajith, Sandya, et al.
Publicado: (2016)

The syntaxins
por: Teng, Felicia Yu Hsuan, et al.
Publicado: (2001)

The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons
por: Soo Hoo, Linda, et al.
Publicado: (2016)

The combinatorial control of alternative splicing in C. elegans
por: Tan, June H., et al.
Publicado: (2017)

The Function of Pre-mRNA Alternative Splicing in Mammal Spermatogenesis
por: Song, Huibin, et al.
Publicado: (2020)

MAP kinase cascades regulating axon regeneration in C. elegans
por: PASTUHOV, Strahil Iv., et al.
Publicado: (2015)

Co-regulation of alternative splicing by diverse splicing factors in Caenorhabditis elegans
por: Barberan-Soler, Sergio, et al.
Publicado: (2011)

The lack of the Celf2a splicing factor converts a Duchenne genotype into a Becker phenotype
por: Martone, J., et al.
Publicado: (2016)

RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery
por: Chatrikhi, Rakesh, et al.
Publicado: (2019)

Motor Neuron Synapse and Axon Defects in a C. elegans Alpha-Tubulin Mutant
por: Baran, Renee, et al.
Publicado: (2010)

Altered CELF1 binding to target transcripts in malignant T cells
por: Bohjanen, Paul R., et al.
Publicado: (2015)

C. elegans VWA-8 is a mitochondrial protein
por: Zhu, Ming, et al.
Publicado: (2020)

A null mutation of C. elegans vwa-8
por: Zhu, Ming, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_d1s9mp5cv7mm63h1dfbe6kui1o