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TTC39B Deficiency Stabilizes LXR Reducing both Atherosclerosis and Steatohepatitis
Cellular mechanisms that mediate steato-hepatitis, an increasingly prevalent condition in the Western world for which no therapies are available(1), are poorly understood. Despite the fact its synthetic agonists induce fatty liver, the Liver X receptor (LXR) transcription factor remains a target of...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947007/ https://www.ncbi.nlm.nih.gov/pubmed/27383786 http://dx.doi.org/10.1038/nature18628 |