TTC39B Deficiency Stabilizes LXR Reducing both Atherosclerosis and Steatohepatitis

Cellular mechanisms that mediate steato-hepatitis, an increasingly prevalent condition in the Western world for which no therapies are available(1), are poorly understood. Despite the fact its synthetic agonists induce fatty liver, the Liver X receptor (LXR) transcription factor remains a target of...

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Detalles Bibliográficos
Autores principales: Hsieh, Joanne, Koseki, Masahiro, Molusky, Matthew M., Yakushiji, Emi, Ichi, Ikuyo, Westerterp, Marit, Iqbal, Jahangir, Chan, Robin B., Abramowicz, Sandra, Tascau, Liana, Takiguchi, Shunichi, Yamashita, Shizuya, Welch, Carrie L., Di Paolo, Gilbert, Hussain, M. Mahmood, Lefkowitch, Jay H., Rader, Daniel J., Tall, Alan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947007/
https://www.ncbi.nlm.nih.gov/pubmed/27383786
http://dx.doi.org/10.1038/nature18628

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