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Soft tissue invasion of papillary thyroid carcinoma
Extrathyroidal extension (ETE) of papillary thyroid carcinoma (PTC) is common and clinical presentation can vary from minimal to extensive locoregional involvement. Although PTC is generally considered the most benign among all thyroid carcinomas, it may present with local invasion with poor prognos...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Netherlands
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947096/ https://www.ncbi.nlm.nih.gov/pubmed/27154220 http://dx.doi.org/10.1007/s10585-016-9800-3 |
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author | Lin, Jen-Der Hsueh, Chuen Chao, Tzu-Chieh |
author_facet | Lin, Jen-Der Hsueh, Chuen Chao, Tzu-Chieh |
author_sort | Lin, Jen-Der |
collection | PubMed |
description | Extrathyroidal extension (ETE) of papillary thyroid carcinoma (PTC) is common and clinical presentation can vary from minimal to extensive locoregional involvement. Although PTC is generally considered the most benign among all thyroid carcinomas, it may present with local invasion with poor prognosis. Our retrospective study involved 3267 PTC patients undergoing regular follow-up at Chang Gung Medical Center in Linkou, Taiwan. Among them, 269 were PTC cases with ETE, having tumors greater than 1 cm in size and treated with total or complete thyroidectomy with or without lymph node dissection for which the follow-up period was over 10 years. The mean age of 269 cases was 46.8 ± 15.1 (range 11–83 years) years. The number of females was 204 (75.8 %). Patients were categorized into minimal ETE (175 cases) and extensive ETE (94 cases) groups according to surgical findings and pathological reports. Mean follow-up period was 13.3 ± 5.5 (range 0.2–29.3) years, during which 28 (10.4 %) patients died of thyroid cancer; and 63 (23.4 %) of all-cause mortality. Multivariate analysis showed that age, gender, extensive ETE, and lymph node metastasis had a statistically significant effect on thyroid cancer mortality. Survival rates were significantly different between minimal ETE and extensive ETE groups (p < 0.0001). In conclusion, perithyroidal soft tissue involvement by PTC is an important factor that determines patient prognosis and a closer follow-up and more aggressive treatment is necessary for patients who are old, male, extensive ETE, and with lymph node involvement. |
format | Online Article Text |
id | pubmed-4947096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-49470962016-07-26 Soft tissue invasion of papillary thyroid carcinoma Lin, Jen-Der Hsueh, Chuen Chao, Tzu-Chieh Clin Exp Metastasis Research Paper Extrathyroidal extension (ETE) of papillary thyroid carcinoma (PTC) is common and clinical presentation can vary from minimal to extensive locoregional involvement. Although PTC is generally considered the most benign among all thyroid carcinomas, it may present with local invasion with poor prognosis. Our retrospective study involved 3267 PTC patients undergoing regular follow-up at Chang Gung Medical Center in Linkou, Taiwan. Among them, 269 were PTC cases with ETE, having tumors greater than 1 cm in size and treated with total or complete thyroidectomy with or without lymph node dissection for which the follow-up period was over 10 years. The mean age of 269 cases was 46.8 ± 15.1 (range 11–83 years) years. The number of females was 204 (75.8 %). Patients were categorized into minimal ETE (175 cases) and extensive ETE (94 cases) groups according to surgical findings and pathological reports. Mean follow-up period was 13.3 ± 5.5 (range 0.2–29.3) years, during which 28 (10.4 %) patients died of thyroid cancer; and 63 (23.4 %) of all-cause mortality. Multivariate analysis showed that age, gender, extensive ETE, and lymph node metastasis had a statistically significant effect on thyroid cancer mortality. Survival rates were significantly different between minimal ETE and extensive ETE groups (p < 0.0001). In conclusion, perithyroidal soft tissue involvement by PTC is an important factor that determines patient prognosis and a closer follow-up and more aggressive treatment is necessary for patients who are old, male, extensive ETE, and with lymph node involvement. Springer Netherlands 2016-05-06 2016 /pmc/articles/PMC4947096/ /pubmed/27154220 http://dx.doi.org/10.1007/s10585-016-9800-3 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Research Paper Lin, Jen-Der Hsueh, Chuen Chao, Tzu-Chieh Soft tissue invasion of papillary thyroid carcinoma |
title | Soft tissue invasion of papillary thyroid carcinoma |
title_full | Soft tissue invasion of papillary thyroid carcinoma |
title_fullStr | Soft tissue invasion of papillary thyroid carcinoma |
title_full_unstemmed | Soft tissue invasion of papillary thyroid carcinoma |
title_short | Soft tissue invasion of papillary thyroid carcinoma |
title_sort | soft tissue invasion of papillary thyroid carcinoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947096/ https://www.ncbi.nlm.nih.gov/pubmed/27154220 http://dx.doi.org/10.1007/s10585-016-9800-3 |
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