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Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

Endosomal-autophagic-lysosomal (EAL) dysfunction is an early and prominent neuropathological feature of Alzheimers’s disease, yet the exact molecular mechanisms contributing to this pathology remain undefined. By combined biochemical, immunohistochemical and ultrastructural approaches, we demonstrat...

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Detalles Bibliográficos
Autores principales:	Lauritzen, Inger, Pardossi-Piquard, Raphaëlle, Bourgeois, Alexandre, Pagnotta, Sophie, Biferi, Maria-Grazia, Barkats, Martine, Lacor, Pascale, Klein, William, Bauer, Charlotte, Checler, Frederic
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2016
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947121/ https://www.ncbi.nlm.nih.gov/pubmed/27138984 http://dx.doi.org/10.1007/s00401-016-1577-6

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