Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by amyloid plaques composed of the β-amyloid (Aβ) peptide surrounded by swollen presynaptic dystrophic neurites consisting of dysfunctional axons and terminals that accumulate the β-site amyloid precursor protein (APP) cleaving enzyme (BACE1) required for Aβ...

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Detalles Bibliográficos
Autores principales: Sadleir, Katherine R., Kandalepas, Patty C., Buggia-Prévot, Virginie, Nicholson, Daniel A., Thinakaran, Gopal, Vassar, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947125/
https://www.ncbi.nlm.nih.gov/pubmed/26993139
http://dx.doi.org/10.1007/s00401-016-1558-9

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