Structural basis of transcobalamin recognition by human CD320 receptor

Cellular uptake of vitamin B12 (cobalamin) requires capture of transcobalamin (TC) from the plasma by CD320, a ubiquitous cell surface receptor of the LDLR family. Here we present the crystal structure of human holo-TC in complex with the extracellular domain of CD320, visualizing the structural bas...

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Detalles Bibliográficos
Autores principales: Alam, Amer, Woo, Jae-Sung, Schmitz, Jennifer, Prinz, Bernadette, Root, Katharina, Chen, Fan, Bloch, Joël S., Zenobi, Renato, Locher, Kaspar P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947154/
https://www.ncbi.nlm.nih.gov/pubmed/27411955
http://dx.doi.org/10.1038/ncomms12100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947154/
https://www.ncbi.nlm.nih.gov/pubmed/27411955
http://dx.doi.org/10.1038/ncomms12100

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