Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia

Sphingosine-1-phosphate (S1P) is a bioactive signalling lipid highly enriched in mature erythrocytes, with unknown functions pertaining to erythrocyte physiology. Here by employing nonbiased high-throughput metabolomic profiling, we show that erythrocyte S1P levels rapidly increase in 21 healthy low...

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Detalles Bibliográficos
Autores principales: Sun, Kaiqi, Zhang, Yujin, D'Alessandro, Angelo, Nemkov, Travis, Song, Anren, Wu, Hongyu, Liu, Hong, Adebiyi, Morayo, Huang, Aji, Wen, Yuan E., Bogdanov, Mikhail V., Vila, Alejandro, O'Brien, John, Kellems, Rodney E., Dowhan, William, Subudhi, Andrew W., Jameson-Van Houten, Sonja, Julian, Colleen G., Lovering, Andrew T., Safo, Martin, Hansen, Kirk C., Roach, Robert C., Xia, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947158/
https://www.ncbi.nlm.nih.gov/pubmed/27417539
http://dx.doi.org/10.1038/ncomms12086

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