Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes

Tuberous sclerosis complex-1 or 2 (TSC1/2) mutations cause white matter abnormalities, including myelin deficits in the CNS; however, underlying mechanisms are not fully understood. TSC1/2 negatively regulate the function of mTOR, which is required for oligodendrocyte differentiation. Here we report...

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Detalles Bibliográficos
Autores principales: Jiang, Minqing, Liu, Lei, He, Xuelian, Wang, Haibo, Lin, Wensheng, Wang, Huimin, Yoon, Sung O., Wood, Teresa L., Lu, Q. Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947172/
https://www.ncbi.nlm.nih.gov/pubmed/27416896
http://dx.doi.org/10.1038/ncomms12185

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