SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding

SREBP1c is a key lipogenic transcription factor activated by insulin in the postprandial state. Although SREBP1c appears to be involved in suppression of hepatic gluconeogenesis, the molecular mechanism is not thoroughly understood. Here we show that CRY1 is activated by insulin-induced SREBP1c and...

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Detalles Bibliográficos
Autores principales: Jang, Hagoon, Lee, Gha Young, Selby, Christopher P., Lee, Gung, Jeon, Yong Geun, Lee, Jae Ho, Cheng, Kenneth King Yip, Titchenell, Paul, Birnbaum, Morris J., Xu, Aimin, Sancar, Aziz, Kim, Jae Bum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947181/
https://www.ncbi.nlm.nih.gov/pubmed/27412556
http://dx.doi.org/10.1038/ncomms12180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947181/
https://www.ncbi.nlm.nih.gov/pubmed/27412556
http://dx.doi.org/10.1038/ncomms12180

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