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Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex

Nucleation of branched actin filaments by Arp2/3 complex is tightly regulated to control actin assembly in cells. Arp2/3 complex activation involves conformational changes brought about by ATP, Nucleation Promoting Factor (NPF) proteins, actin filaments and NPF-recruited actin monomers. To understan...

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Detalles Bibliográficos
Autores principales:	Rodnick-Smith, Max, Liu, Su-Ling, Balzer, Connor J., Luan, Qing, Nolen, Brad J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947185/ https://www.ncbi.nlm.nih.gov/pubmed/27417392 http://dx.doi.org/10.1038/ncomms12226

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