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The role of atorvastatin on the restenosis process post-PTA in a diabetic rabbit model

BACKGROUND: Restenosis remains to be a major limitation of percutaneous transluminal angioplasty (PTA) for diabetic patients with peripheral vascular disease (PVD). Despite of stations routine implements to prevent such progress, its exact effect is unclear. METHODS AND RESULTS: In our study, balloo...

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Autores principales: Zhou, Xiaojun, Mou, Yaru, Shen, Xue, Yang, Tianshu, Liu, Ju, Liu, Fupeng, Dong, Jianjun, Liao, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947282/
https://www.ncbi.nlm.nih.gov/pubmed/27422557
http://dx.doi.org/10.1186/s12872-016-0324-1
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author Zhou, Xiaojun
Mou, Yaru
Shen, Xue
Yang, Tianshu
Liu, Ju
Liu, Fupeng
Dong, Jianjun
Liao, Lin
author_facet Zhou, Xiaojun
Mou, Yaru
Shen, Xue
Yang, Tianshu
Liu, Ju
Liu, Fupeng
Dong, Jianjun
Liao, Lin
author_sort Zhou, Xiaojun
collection PubMed
description BACKGROUND: Restenosis remains to be a major limitation of percutaneous transluminal angioplasty (PTA) for diabetic patients with peripheral vascular disease (PVD). Despite of stations routine implements to prevent such progress, its exact effect is unclear. METHODS AND RESULTS: In our study, balloon was successfully implanted in the iliac artery of atherosclerotic rabbit. Patency of the narrowed artery was interrogated using ultrasound. Atorvastatin or vehicle was administered orally to rabbits from day 0 to day 28 after double-injury surgery. On day 7, day 14, and day 28, restenotic arteries were harvested and processed for histopathlogical analysis. Our data show that, after double-injury surgery, the intima was composed mostly by SMCs at all time course in rabbits undergoing surgery process. Significant increases in stenosis rates were noted from day 7 to day 14 (from 21 ± 5.85 % to 60.93 ± 12.46 %). On day 28 after double-injury surgery, severe restenosis was observed and daily administration of atorvastatin cannot prevent restenosis’ formation (88.69 ± 3.71 % vs. 90.02 ± 3.11 %, P > 0.05). The PCNA index and SMCs proliferation were correlated with the scores of the vascular pathology. CONCLUSIONS: Our results indicate that double-injury model can mimic clinical restenosis, based on this model, atorvastatin showed no therapeutic effect on restenosis process in diabetic rabbits after PTA.
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spelling pubmed-49472822016-07-17 The role of atorvastatin on the restenosis process post-PTA in a diabetic rabbit model Zhou, Xiaojun Mou, Yaru Shen, Xue Yang, Tianshu Liu, Ju Liu, Fupeng Dong, Jianjun Liao, Lin BMC Cardiovasc Disord Research Article BACKGROUND: Restenosis remains to be a major limitation of percutaneous transluminal angioplasty (PTA) for diabetic patients with peripheral vascular disease (PVD). Despite of stations routine implements to prevent such progress, its exact effect is unclear. METHODS AND RESULTS: In our study, balloon was successfully implanted in the iliac artery of atherosclerotic rabbit. Patency of the narrowed artery was interrogated using ultrasound. Atorvastatin or vehicle was administered orally to rabbits from day 0 to day 28 after double-injury surgery. On day 7, day 14, and day 28, restenotic arteries were harvested and processed for histopathlogical analysis. Our data show that, after double-injury surgery, the intima was composed mostly by SMCs at all time course in rabbits undergoing surgery process. Significant increases in stenosis rates were noted from day 7 to day 14 (from 21 ± 5.85 % to 60.93 ± 12.46 %). On day 28 after double-injury surgery, severe restenosis was observed and daily administration of atorvastatin cannot prevent restenosis’ formation (88.69 ± 3.71 % vs. 90.02 ± 3.11 %, P > 0.05). The PCNA index and SMCs proliferation were correlated with the scores of the vascular pathology. CONCLUSIONS: Our results indicate that double-injury model can mimic clinical restenosis, based on this model, atorvastatin showed no therapeutic effect on restenosis process in diabetic rabbits after PTA. BioMed Central 2016-07-16 /pmc/articles/PMC4947282/ /pubmed/27422557 http://dx.doi.org/10.1186/s12872-016-0324-1 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Zhou, Xiaojun
Mou, Yaru
Shen, Xue
Yang, Tianshu
Liu, Ju
Liu, Fupeng
Dong, Jianjun
Liao, Lin
The role of atorvastatin on the restenosis process post-PTA in a diabetic rabbit model
title The role of atorvastatin on the restenosis process post-PTA in a diabetic rabbit model
title_full The role of atorvastatin on the restenosis process post-PTA in a diabetic rabbit model
title_fullStr The role of atorvastatin on the restenosis process post-PTA in a diabetic rabbit model
title_full_unstemmed The role of atorvastatin on the restenosis process post-PTA in a diabetic rabbit model
title_short The role of atorvastatin on the restenosis process post-PTA in a diabetic rabbit model
title_sort role of atorvastatin on the restenosis process post-pta in a diabetic rabbit model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947282/
https://www.ncbi.nlm.nih.gov/pubmed/27422557
http://dx.doi.org/10.1186/s12872-016-0324-1
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