Genetic, hormonal and metabolic aspects of PCOS: an update

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting 5–10 % of women of reproductive age. It generally manifests with oligo/anovulatory cycles, hirsutism and polycystic ovaries, together with a considerable prevalence of insulin resistance. Although the aetiology of the syndrom...

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Autores principales: De Leo, V., Musacchio, M. C., Cappelli, V., Massaro, M. G., Morgante, G., Petraglia, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947298/
https://www.ncbi.nlm.nih.gov/pubmed/27423183
http://dx.doi.org/10.1186/s12958-016-0173-x
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author De Leo, V.
Musacchio, M. C.
Cappelli, V.
Massaro, M. G.
Morgante, G.
Petraglia, F.
author_facet De Leo, V.
Musacchio, M. C.
Cappelli, V.
Massaro, M. G.
Morgante, G.
Petraglia, F.
author_sort De Leo, V.
collection PubMed
description Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting 5–10 % of women of reproductive age. It generally manifests with oligo/anovulatory cycles, hirsutism and polycystic ovaries, together with a considerable prevalence of insulin resistance. Although the aetiology of the syndrome is not completely understood yet, PCOS is considered a multifactorial disorder with various genetic, endocrine and environmental abnormalities. Moreover, PCOS patients have a higher risk of metabolic and cardiovascular diseases and their related morbidity, if compared to the general population.
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spelling pubmed-49472982016-07-17 Genetic, hormonal and metabolic aspects of PCOS: an update De Leo, V. Musacchio, M. C. Cappelli, V. Massaro, M. G. Morgante, G. Petraglia, F. Reprod Biol Endocrinol Review Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting 5–10 % of women of reproductive age. It generally manifests with oligo/anovulatory cycles, hirsutism and polycystic ovaries, together with a considerable prevalence of insulin resistance. Although the aetiology of the syndrome is not completely understood yet, PCOS is considered a multifactorial disorder with various genetic, endocrine and environmental abnormalities. Moreover, PCOS patients have a higher risk of metabolic and cardiovascular diseases and their related morbidity, if compared to the general population. BioMed Central 2016-07-16 /pmc/articles/PMC4947298/ /pubmed/27423183 http://dx.doi.org/10.1186/s12958-016-0173-x Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
De Leo, V.
Musacchio, M. C.
Cappelli, V.
Massaro, M. G.
Morgante, G.
Petraglia, F.
Genetic, hormonal and metabolic aspects of PCOS: an update
title Genetic, hormonal and metabolic aspects of PCOS: an update
title_full Genetic, hormonal and metabolic aspects of PCOS: an update
title_fullStr Genetic, hormonal and metabolic aspects of PCOS: an update
title_full_unstemmed Genetic, hormonal and metabolic aspects of PCOS: an update
title_short Genetic, hormonal and metabolic aspects of PCOS: an update
title_sort genetic, hormonal and metabolic aspects of pcos: an update
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947298/
https://www.ncbi.nlm.nih.gov/pubmed/27423183
http://dx.doi.org/10.1186/s12958-016-0173-x
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