The hnRNP family: insights into their role in health and disease

Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. Many hnRNPs share general fea...

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Detalles Bibliográficos
Autores principales: Geuens, Thomas, Bouhy, Delphine, Timmerman, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947485/
https://www.ncbi.nlm.nih.gov/pubmed/27215579
http://dx.doi.org/10.1007/s00439-016-1683-5
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author Geuens, Thomas
Bouhy, Delphine
Timmerman, Vincent
author_facet Geuens, Thomas
Bouhy, Delphine
Timmerman, Vincent
author_sort Geuens, Thomas
collection PubMed
description Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. Many hnRNPs share general features, but differ in domain composition and functional properties. This review will discuss the current knowledge about the different hnRNP family members, focusing on their structural and functional divergence. Additionally, we will highlight their involvement in neurodegenerative diseases and cancer, and the potential to develop RNA-based therapies.
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spelling pubmed-49474852016-07-26 The hnRNP family: insights into their role in health and disease Geuens, Thomas Bouhy, Delphine Timmerman, Vincent Hum Genet Review Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. Many hnRNPs share general features, but differ in domain composition and functional properties. This review will discuss the current knowledge about the different hnRNP family members, focusing on their structural and functional divergence. Additionally, we will highlight their involvement in neurodegenerative diseases and cancer, and the potential to develop RNA-based therapies. Springer Berlin Heidelberg 2016-05-23 2016 /pmc/articles/PMC4947485/ /pubmed/27215579 http://dx.doi.org/10.1007/s00439-016-1683-5 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Geuens, Thomas
Bouhy, Delphine
Timmerman, Vincent
The hnRNP family: insights into their role in health and disease
title The hnRNP family: insights into their role in health and disease
title_full The hnRNP family: insights into their role in health and disease
title_fullStr The hnRNP family: insights into their role in health and disease
title_full_unstemmed The hnRNP family: insights into their role in health and disease
title_short The hnRNP family: insights into their role in health and disease
title_sort hnrnp family: insights into their role in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947485/
https://www.ncbi.nlm.nih.gov/pubmed/27215579
http://dx.doi.org/10.1007/s00439-016-1683-5
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