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Biomechanical Measurement of Rabbit Cornea by a Modified Scheimpflug Device
Purpose. To explore the probability and variation in biomechanical measurements of rabbit cornea by a modified Scheimpflug device. Methods. A modified Scheimpflug device was developed by imaging anterior segment of the model imitating the intact eye at various posterior pressures. The eight isolated...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947499/ https://www.ncbi.nlm.nih.gov/pubmed/27446608 http://dx.doi.org/10.1155/2016/8271762 |
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author | Zhang, Bo Gu, Jianjun Zhang, Xiaoxiao Yang, Bin Wang, Zheng Zheng, Danying |
author_facet | Zhang, Bo Gu, Jianjun Zhang, Xiaoxiao Yang, Bin Wang, Zheng Zheng, Danying |
author_sort | Zhang, Bo |
collection | PubMed |
description | Purpose. To explore the probability and variation in biomechanical measurements of rabbit cornea by a modified Scheimpflug device. Methods. A modified Scheimpflug device was developed by imaging anterior segment of the model imitating the intact eye at various posterior pressures. The eight isolated rabbit corneas were mounted on the Barron artificial chamber and images of the anterior segment were taken at posterior pressures of 15, 30, 45, 60, and 75 mmHg by the device. The repeatability and reliability of the parameters including CCT, ACD, ACV, and CV were evaluated at each posterior pressure. All the variations of the parameters at the different posterior pressures were calculated. Results. All parameters showed good intraobserver reliability (Cronbach's alpha; intraclass correlation coefficient, α, ICC > 0.96) and repeatability in the modified Scheimpflug device. With the increase of posterior pressures, the ratio of CCT decreased linearly and the bulk modulus gradually reduced to a platform. The increase of ACD was almost linear with the posterior pressures elevated. Conclusions. The modified Scheimpflug device was a valuable tool to investigate the biomechanics of the cornea. The posterior pressure 15–75 mmHg range produced small viscoelastic deformations and nearly linear pressure-deformation response in the rabbit cornea. |
format | Online Article Text |
id | pubmed-4947499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-49474992016-07-21 Biomechanical Measurement of Rabbit Cornea by a Modified Scheimpflug Device Zhang, Bo Gu, Jianjun Zhang, Xiaoxiao Yang, Bin Wang, Zheng Zheng, Danying J Ophthalmol Research Article Purpose. To explore the probability and variation in biomechanical measurements of rabbit cornea by a modified Scheimpflug device. Methods. A modified Scheimpflug device was developed by imaging anterior segment of the model imitating the intact eye at various posterior pressures. The eight isolated rabbit corneas were mounted on the Barron artificial chamber and images of the anterior segment were taken at posterior pressures of 15, 30, 45, 60, and 75 mmHg by the device. The repeatability and reliability of the parameters including CCT, ACD, ACV, and CV were evaluated at each posterior pressure. All the variations of the parameters at the different posterior pressures were calculated. Results. All parameters showed good intraobserver reliability (Cronbach's alpha; intraclass correlation coefficient, α, ICC > 0.96) and repeatability in the modified Scheimpflug device. With the increase of posterior pressures, the ratio of CCT decreased linearly and the bulk modulus gradually reduced to a platform. The increase of ACD was almost linear with the posterior pressures elevated. Conclusions. The modified Scheimpflug device was a valuable tool to investigate the biomechanics of the cornea. The posterior pressure 15–75 mmHg range produced small viscoelastic deformations and nearly linear pressure-deformation response in the rabbit cornea. Hindawi Publishing Corporation 2016 2016-07-03 /pmc/articles/PMC4947499/ /pubmed/27446608 http://dx.doi.org/10.1155/2016/8271762 Text en Copyright © 2016 Bo Zhang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhang, Bo Gu, Jianjun Zhang, Xiaoxiao Yang, Bin Wang, Zheng Zheng, Danying Biomechanical Measurement of Rabbit Cornea by a Modified Scheimpflug Device |
title | Biomechanical Measurement of Rabbit Cornea by a Modified Scheimpflug Device |
title_full | Biomechanical Measurement of Rabbit Cornea by a Modified Scheimpflug Device |
title_fullStr | Biomechanical Measurement of Rabbit Cornea by a Modified Scheimpflug Device |
title_full_unstemmed | Biomechanical Measurement of Rabbit Cornea by a Modified Scheimpflug Device |
title_short | Biomechanical Measurement of Rabbit Cornea by a Modified Scheimpflug Device |
title_sort | biomechanical measurement of rabbit cornea by a modified scheimpflug device |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947499/ https://www.ncbi.nlm.nih.gov/pubmed/27446608 http://dx.doi.org/10.1155/2016/8271762 |
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