A Canonical Correlation Analysis of AIDS Restriction Genes and Metabolic Pathways Identifies Purine Metabolism as a Key Cooperator

Human immunodeficiency virus causes a severe disease in humans, referred to as immune deficiency syndrome. Studies on the interaction between host genetic factors and the virus have revealed dozens of genes that impact diverse processes in the AIDS disease. To resolve more genetic factors related to...

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Autores principales: Ye, Hanhui, Yuan, Jinjin, Wang, Zhengwu, Huang, Aiqiong, Liu, Xiaolong, Han, Xiao, Chen, Yahong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947641/
https://www.ncbi.nlm.nih.gov/pubmed/27462363
http://dx.doi.org/10.1155/2016/2460184
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author Ye, Hanhui
Yuan, Jinjin
Wang, Zhengwu
Huang, Aiqiong
Liu, Xiaolong
Han, Xiao
Chen, Yahong
author_facet Ye, Hanhui
Yuan, Jinjin
Wang, Zhengwu
Huang, Aiqiong
Liu, Xiaolong
Han, Xiao
Chen, Yahong
author_sort Ye, Hanhui
collection PubMed
description Human immunodeficiency virus causes a severe disease in humans, referred to as immune deficiency syndrome. Studies on the interaction between host genetic factors and the virus have revealed dozens of genes that impact diverse processes in the AIDS disease. To resolve more genetic factors related to AIDS, a canonical correlation analysis was used to determine the correlation between AIDS restriction and metabolic pathway gene expression. The results show that HIV-1 postentry cellular viral cofactors from AIDS restriction genes are coexpressed in human transcriptome microarray datasets. Further, the purine metabolism pathway comprises novel host factors that are coexpressed with AIDS restriction genes. Using a canonical correlation analysis for expression is a reliable approach to exploring the mechanism underlying AIDS.
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spelling pubmed-49476412016-07-26 A Canonical Correlation Analysis of AIDS Restriction Genes and Metabolic Pathways Identifies Purine Metabolism as a Key Cooperator Ye, Hanhui Yuan, Jinjin Wang, Zhengwu Huang, Aiqiong Liu, Xiaolong Han, Xiao Chen, Yahong Comput Math Methods Med Research Article Human immunodeficiency virus causes a severe disease in humans, referred to as immune deficiency syndrome. Studies on the interaction between host genetic factors and the virus have revealed dozens of genes that impact diverse processes in the AIDS disease. To resolve more genetic factors related to AIDS, a canonical correlation analysis was used to determine the correlation between AIDS restriction and metabolic pathway gene expression. The results show that HIV-1 postentry cellular viral cofactors from AIDS restriction genes are coexpressed in human transcriptome microarray datasets. Further, the purine metabolism pathway comprises novel host factors that are coexpressed with AIDS restriction genes. Using a canonical correlation analysis for expression is a reliable approach to exploring the mechanism underlying AIDS. Hindawi Publishing Corporation 2016 2016-07-04 /pmc/articles/PMC4947641/ /pubmed/27462363 http://dx.doi.org/10.1155/2016/2460184 Text en Copyright © 2016 Hanhui Ye et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ye, Hanhui
Yuan, Jinjin
Wang, Zhengwu
Huang, Aiqiong
Liu, Xiaolong
Han, Xiao
Chen, Yahong
A Canonical Correlation Analysis of AIDS Restriction Genes and Metabolic Pathways Identifies Purine Metabolism as a Key Cooperator
title A Canonical Correlation Analysis of AIDS Restriction Genes and Metabolic Pathways Identifies Purine Metabolism as a Key Cooperator
title_full A Canonical Correlation Analysis of AIDS Restriction Genes and Metabolic Pathways Identifies Purine Metabolism as a Key Cooperator
title_fullStr A Canonical Correlation Analysis of AIDS Restriction Genes and Metabolic Pathways Identifies Purine Metabolism as a Key Cooperator
title_full_unstemmed A Canonical Correlation Analysis of AIDS Restriction Genes and Metabolic Pathways Identifies Purine Metabolism as a Key Cooperator
title_short A Canonical Correlation Analysis of AIDS Restriction Genes and Metabolic Pathways Identifies Purine Metabolism as a Key Cooperator
title_sort canonical correlation analysis of aids restriction genes and metabolic pathways identifies purine metabolism as a key cooperator
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947641/
https://www.ncbi.nlm.nih.gov/pubmed/27462363
http://dx.doi.org/10.1155/2016/2460184
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