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The Application of OCTA in Assessment of Anti-VEGF Therapy for Idiopathic Choroidal Neovascularization
Purpose. To assess the morphology of idiopathic choroidal neovascularization (ICNV) by optical coherence tomography angiography (OCTA) and determine the therapeutic effects of intravitreal antivascular endothelial growth factor (anti-VEGF). Method. Patients with naive ICNV were assessed by spectral...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947658/ https://www.ncbi.nlm.nih.gov/pubmed/27471600 http://dx.doi.org/10.1155/2016/5608250 |
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author | Chen, Qin Yu, Xiaobing Sun, Zihan Dai, Hong |
author_facet | Chen, Qin Yu, Xiaobing Sun, Zihan Dai, Hong |
author_sort | Chen, Qin |
collection | PubMed |
description | Purpose. To assess the morphology of idiopathic choroidal neovascularization (ICNV) by optical coherence tomography angiography (OCTA) and determine the therapeutic effects of intravitreal antivascular endothelial growth factor (anti-VEGF). Method. Patients with naive ICNV were assessed by spectral domain optical coherence tomography (SD-OCT) and OCTA in this observational study. The timing of observation was before treatment, 1 day after treatment with intravitreal anti-VEGF injection, and 1 month after the treatment. The central retina thickness (CRT) on SD-OCT, selected CNV area, and flow area on OCTA were measured. Results. A total of 17 eyes from 17 patients with ICNV were included in this study. OCTA showed visible irregular choroidal neovascularization with “tree-in-bud” form on outer retinal layer. After treatment, as well as in the 1-day follow-up, CNV decreased in size from the periphery, and the vessel density was reduced. As shown on OCTA, the selected CNV area and flow area were significantly reduced compared to pretreatment. The rate of CNV vessel area changes was higher on OCTA than the changes in CRT on SD-OCT at 1-day and 1-month follow-up. Conclusion. Intravitreal injection of anti-VEGF is effective for idiopathic choroidal neovascularization, and the treatment outcomes are observable after 1 day. OCTA provides a useful approach for monitoring and evaluating the treatment of intravitreal anti-VEGF for CNV. |
format | Online Article Text |
id | pubmed-4947658 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-49476582016-07-28 The Application of OCTA in Assessment of Anti-VEGF Therapy for Idiopathic Choroidal Neovascularization Chen, Qin Yu, Xiaobing Sun, Zihan Dai, Hong J Ophthalmol Clinical Study Purpose. To assess the morphology of idiopathic choroidal neovascularization (ICNV) by optical coherence tomography angiography (OCTA) and determine the therapeutic effects of intravitreal antivascular endothelial growth factor (anti-VEGF). Method. Patients with naive ICNV were assessed by spectral domain optical coherence tomography (SD-OCT) and OCTA in this observational study. The timing of observation was before treatment, 1 day after treatment with intravitreal anti-VEGF injection, and 1 month after the treatment. The central retina thickness (CRT) on SD-OCT, selected CNV area, and flow area on OCTA were measured. Results. A total of 17 eyes from 17 patients with ICNV were included in this study. OCTA showed visible irregular choroidal neovascularization with “tree-in-bud” form on outer retinal layer. After treatment, as well as in the 1-day follow-up, CNV decreased in size from the periphery, and the vessel density was reduced. As shown on OCTA, the selected CNV area and flow area were significantly reduced compared to pretreatment. The rate of CNV vessel area changes was higher on OCTA than the changes in CRT on SD-OCT at 1-day and 1-month follow-up. Conclusion. Intravitreal injection of anti-VEGF is effective for idiopathic choroidal neovascularization, and the treatment outcomes are observable after 1 day. OCTA provides a useful approach for monitoring and evaluating the treatment of intravitreal anti-VEGF for CNV. Hindawi Publishing Corporation 2016 2016-07-04 /pmc/articles/PMC4947658/ /pubmed/27471600 http://dx.doi.org/10.1155/2016/5608250 Text en Copyright © 2016 Qin Chen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Chen, Qin Yu, Xiaobing Sun, Zihan Dai, Hong The Application of OCTA in Assessment of Anti-VEGF Therapy for Idiopathic Choroidal Neovascularization |
title | The Application of OCTA in Assessment of Anti-VEGF Therapy for Idiopathic Choroidal Neovascularization |
title_full | The Application of OCTA in Assessment of Anti-VEGF Therapy for Idiopathic Choroidal Neovascularization |
title_fullStr | The Application of OCTA in Assessment of Anti-VEGF Therapy for Idiopathic Choroidal Neovascularization |
title_full_unstemmed | The Application of OCTA in Assessment of Anti-VEGF Therapy for Idiopathic Choroidal Neovascularization |
title_short | The Application of OCTA in Assessment of Anti-VEGF Therapy for Idiopathic Choroidal Neovascularization |
title_sort | application of octa in assessment of anti-vegf therapy for idiopathic choroidal neovascularization |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947658/ https://www.ncbi.nlm.nih.gov/pubmed/27471600 http://dx.doi.org/10.1155/2016/5608250 |
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