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Early prediction of typical outcome and mild developmental delay for prioritisation of service delivery for very preterm and very low birthweight infants: a study protocol

INTRODUCTION: Over 80% of very preterm (<32 weeks) and very low birthweight (<1500 g) infants will have either typical development (TD) or mild developmental delay (MDD) in multiple domains. As differentiation between TD and MDD can be difficult, infants with MDD often miss opportunities for i...

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Autores principales: Caesar, Rebecca, Boyd, Roslyn N, Colditz, Paul, Cioni, Giovani, Ware, Robert S, Salthouse, Kaye, Doherty, Julie, Jackson, Maxine, Matthews, Leanne, Hurley, Tom, Morosini, Anthony, Thomas, Clare, Camadoo, Laxmi, Baer, Erica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947748/
https://www.ncbi.nlm.nih.gov/pubmed/27377633
http://dx.doi.org/10.1136/bmjopen-2015-010726
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author Caesar, Rebecca
Boyd, Roslyn N
Colditz, Paul
Cioni, Giovani
Ware, Robert S
Salthouse, Kaye
Doherty, Julie
Jackson, Maxine
Matthews, Leanne
Hurley, Tom
Morosini, Anthony
Thomas, Clare
Camadoo, Laxmi
Baer, Erica
author_facet Caesar, Rebecca
Boyd, Roslyn N
Colditz, Paul
Cioni, Giovani
Ware, Robert S
Salthouse, Kaye
Doherty, Julie
Jackson, Maxine
Matthews, Leanne
Hurley, Tom
Morosini, Anthony
Thomas, Clare
Camadoo, Laxmi
Baer, Erica
author_sort Caesar, Rebecca
collection PubMed
description INTRODUCTION: Over 80% of very preterm (<32 weeks) and very low birthweight (<1500 g) infants will have either typical development (TD) or mild developmental delay (MDD) in multiple domains. As differentiation between TD and MDD can be difficult, infants with MDD often miss opportunities for intervention. For many clinicians, the ongoing challenge is early detection of MDD without over servicing the population. This study aims to: (1) identify early clinical biomarkers for use in this population to predict and differentiate between TD and MDD at 24 months corrected age. (2) Determine the extent to which family and caregiver factors will contribute to neurodevelopmental and behavioural outcomes. METHODS AND ANALYSIS: Participants will be a prospective cohort of 90 infants (<32 weeks and/or <1500 g). Between 34 weeks gestational age and 16 weeks post-term, infants will have a series of 5 neurological, neuromotor, neurobehavioural and perceptual assessments including General Movement Assessment at preterm, writhing and fidgety age. Primary caregivers will complete questionnaires to identify social risk, maternal depression and family strain. Extensive perinatal data will be collected from the medical record. At 24 months, corrected age (c.a) infants will be assessed using standardised tools including the Bayley Scales of Infant and Toddler Development—Third Edition (Bayley III). Longitudinal trajectories of early assessment findings will be examined to determine any predictive relationship with motor and cognitive outcomes at 24 months c.a. Published data of a cohort of Australian children assessed with the Bayley III at 24 months c.a will provide a reference group of term-born controls. ETHICS: Ethical approval has been obtained from the Queensland Children's Health Services Human Research Ethics Committee (HREC/13/QRCH/66), the University of Queensland (2013001019) and the Sunshine Coast Hospital and Health Service, SC-Research Governance (SSA/13/QNB/66). Publication of all study outcomes will be in peer-reviewed journals. TRIAL REGISTRATION NUMBER: ACTRN12614000480684; Pre-results.
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spelling pubmed-49477482016-08-03 Early prediction of typical outcome and mild developmental delay for prioritisation of service delivery for very preterm and very low birthweight infants: a study protocol Caesar, Rebecca Boyd, Roslyn N Colditz, Paul Cioni, Giovani Ware, Robert S Salthouse, Kaye Doherty, Julie Jackson, Maxine Matthews, Leanne Hurley, Tom Morosini, Anthony Thomas, Clare Camadoo, Laxmi Baer, Erica BMJ Open Paediatrics INTRODUCTION: Over 80% of very preterm (<32 weeks) and very low birthweight (<1500 g) infants will have either typical development (TD) or mild developmental delay (MDD) in multiple domains. As differentiation between TD and MDD can be difficult, infants with MDD often miss opportunities for intervention. For many clinicians, the ongoing challenge is early detection of MDD without over servicing the population. This study aims to: (1) identify early clinical biomarkers for use in this population to predict and differentiate between TD and MDD at 24 months corrected age. (2) Determine the extent to which family and caregiver factors will contribute to neurodevelopmental and behavioural outcomes. METHODS AND ANALYSIS: Participants will be a prospective cohort of 90 infants (<32 weeks and/or <1500 g). Between 34 weeks gestational age and 16 weeks post-term, infants will have a series of 5 neurological, neuromotor, neurobehavioural and perceptual assessments including General Movement Assessment at preterm, writhing and fidgety age. Primary caregivers will complete questionnaires to identify social risk, maternal depression and family strain. Extensive perinatal data will be collected from the medical record. At 24 months, corrected age (c.a) infants will be assessed using standardised tools including the Bayley Scales of Infant and Toddler Development—Third Edition (Bayley III). Longitudinal trajectories of early assessment findings will be examined to determine any predictive relationship with motor and cognitive outcomes at 24 months c.a. Published data of a cohort of Australian children assessed with the Bayley III at 24 months c.a will provide a reference group of term-born controls. ETHICS: Ethical approval has been obtained from the Queensland Children's Health Services Human Research Ethics Committee (HREC/13/QRCH/66), the University of Queensland (2013001019) and the Sunshine Coast Hospital and Health Service, SC-Research Governance (SSA/13/QNB/66). Publication of all study outcomes will be in peer-reviewed journals. TRIAL REGISTRATION NUMBER: ACTRN12614000480684; Pre-results. BMJ Publishing Group 2016-07-04 /pmc/articles/PMC4947748/ /pubmed/27377633 http://dx.doi.org/10.1136/bmjopen-2015-010726 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Paediatrics
Caesar, Rebecca
Boyd, Roslyn N
Colditz, Paul
Cioni, Giovani
Ware, Robert S
Salthouse, Kaye
Doherty, Julie
Jackson, Maxine
Matthews, Leanne
Hurley, Tom
Morosini, Anthony
Thomas, Clare
Camadoo, Laxmi
Baer, Erica
Early prediction of typical outcome and mild developmental delay for prioritisation of service delivery for very preterm and very low birthweight infants: a study protocol
title Early prediction of typical outcome and mild developmental delay for prioritisation of service delivery for very preterm and very low birthweight infants: a study protocol
title_full Early prediction of typical outcome and mild developmental delay for prioritisation of service delivery for very preterm and very low birthweight infants: a study protocol
title_fullStr Early prediction of typical outcome and mild developmental delay for prioritisation of service delivery for very preterm and very low birthweight infants: a study protocol
title_full_unstemmed Early prediction of typical outcome and mild developmental delay for prioritisation of service delivery for very preterm and very low birthweight infants: a study protocol
title_short Early prediction of typical outcome and mild developmental delay for prioritisation of service delivery for very preterm and very low birthweight infants: a study protocol
title_sort early prediction of typical outcome and mild developmental delay for prioritisation of service delivery for very preterm and very low birthweight infants: a study protocol
topic Paediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947748/
https://www.ncbi.nlm.nih.gov/pubmed/27377633
http://dx.doi.org/10.1136/bmjopen-2015-010726
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