Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells

The nonclassical HLA molecule MHC-related protein 1 (MR1) presents metabolites of the vitamin B synthesis pathways to mucosal-associated invariant T (MAIT) cells and other MR1-restricted T cells. This new class of Ags represents a variation on the classical paradigm of self/non-self discrimination b...

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Detalles Bibliográficos
Autores principales: Laugel, Bruno, Lloyd, Angharad, Meermeier, Erin W., Crowther, Michael D., Connor, Thomas R., Dolton, Garry, Miles, John J., Burrows, Scott R., Gold, Marielle C., Lewinsohn, David M., Sewell, Andrew K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2016
Materias:
Novel Immunological Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947828/
https://www.ncbi.nlm.nih.gov/pubmed/27307560
http://dx.doi.org/10.4049/jimmunol.1501402

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