Cargando…
COMT and prenatal maternal smoking in associations with conduct problems and crime: the Pelotas 1993 birth cohort study
Conduct problems in childhood and adolescence are significant precursors of crime and violence in young adulthood. The purpose of the current study is to test the interaction between prenatal maternal smoking and COMT Val(158)Met in conduct problems and crime in the 1993 Pelotas Birth Cohort Study....
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947962/ https://www.ncbi.nlm.nih.gov/pubmed/27426045 http://dx.doi.org/10.1038/srep29900 |
_version_ | 1782443260099166208 |
---|---|
author | Salatino-Oliveira, Angélica Murray, Joseph Kieling, Christian Genro, Júlia Pasqualini Polanczyk, Guilherme Anselmi, Luciana Wehrmeister, Fernando de Barros, Fernando C. Menezes, Ana Maria Baptista Rohde, Luis Augusto Hutz, Mara Helena |
author_facet | Salatino-Oliveira, Angélica Murray, Joseph Kieling, Christian Genro, Júlia Pasqualini Polanczyk, Guilherme Anselmi, Luciana Wehrmeister, Fernando de Barros, Fernando C. Menezes, Ana Maria Baptista Rohde, Luis Augusto Hutz, Mara Helena |
author_sort | Salatino-Oliveira, Angélica |
collection | PubMed |
description | Conduct problems in childhood and adolescence are significant precursors of crime and violence in young adulthood. The purpose of the current study is to test the interaction between prenatal maternal smoking and COMT Val(158)Met in conduct problems and crime in the 1993 Pelotas Birth Cohort Study. Conduct problems were assessed through the parent version of the Strengths and Difficulties Questionnaire at ages 11 and 15 years. A translated version of a confidential self-report questionnaire was used to collect criminal data at 18 years of age. Negative binomial regression analyses showed an association between prenatal maternal smoking and SDQ conduct problem scores (IRR = 1.24; 95% CI: 1.14–1.34; p < 0.001) at 11 years of age. However, no evidence was found for an association between COMT genotypes and conduct scores or for an interaction between maternal smoking and this gene in predicting conduct problems. Very similar results were obtained using the 15 years conduct scores and crime measure at age 18. Prenatal maternal smoking was associated with crime (IRR = 1.28; 95% CI: 1.09–1.48; p = 0.002) but neither COMT genotypes nor the possible interaction between gene and maternal smoking were significantly associated with crime. Replications of GxE findings across different social contexts are critical for testing the robustness of findings. |
format | Online Article Text |
id | pubmed-4947962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49479622016-07-26 COMT and prenatal maternal smoking in associations with conduct problems and crime: the Pelotas 1993 birth cohort study Salatino-Oliveira, Angélica Murray, Joseph Kieling, Christian Genro, Júlia Pasqualini Polanczyk, Guilherme Anselmi, Luciana Wehrmeister, Fernando de Barros, Fernando C. Menezes, Ana Maria Baptista Rohde, Luis Augusto Hutz, Mara Helena Sci Rep Article Conduct problems in childhood and adolescence are significant precursors of crime and violence in young adulthood. The purpose of the current study is to test the interaction between prenatal maternal smoking and COMT Val(158)Met in conduct problems and crime in the 1993 Pelotas Birth Cohort Study. Conduct problems were assessed through the parent version of the Strengths and Difficulties Questionnaire at ages 11 and 15 years. A translated version of a confidential self-report questionnaire was used to collect criminal data at 18 years of age. Negative binomial regression analyses showed an association between prenatal maternal smoking and SDQ conduct problem scores (IRR = 1.24; 95% CI: 1.14–1.34; p < 0.001) at 11 years of age. However, no evidence was found for an association between COMT genotypes and conduct scores or for an interaction between maternal smoking and this gene in predicting conduct problems. Very similar results were obtained using the 15 years conduct scores and crime measure at age 18. Prenatal maternal smoking was associated with crime (IRR = 1.28; 95% CI: 1.09–1.48; p = 0.002) but neither COMT genotypes nor the possible interaction between gene and maternal smoking were significantly associated with crime. Replications of GxE findings across different social contexts are critical for testing the robustness of findings. Nature Publishing Group 2016-07-18 /pmc/articles/PMC4947962/ /pubmed/27426045 http://dx.doi.org/10.1038/srep29900 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Salatino-Oliveira, Angélica Murray, Joseph Kieling, Christian Genro, Júlia Pasqualini Polanczyk, Guilherme Anselmi, Luciana Wehrmeister, Fernando de Barros, Fernando C. Menezes, Ana Maria Baptista Rohde, Luis Augusto Hutz, Mara Helena COMT and prenatal maternal smoking in associations with conduct problems and crime: the Pelotas 1993 birth cohort study |
title | COMT and prenatal maternal smoking in associations with conduct problems and crime: the Pelotas 1993 birth cohort study |
title_full | COMT and prenatal maternal smoking in associations with conduct problems and crime: the Pelotas 1993 birth cohort study |
title_fullStr | COMT and prenatal maternal smoking in associations with conduct problems and crime: the Pelotas 1993 birth cohort study |
title_full_unstemmed | COMT and prenatal maternal smoking in associations with conduct problems and crime: the Pelotas 1993 birth cohort study |
title_short | COMT and prenatal maternal smoking in associations with conduct problems and crime: the Pelotas 1993 birth cohort study |
title_sort | comt and prenatal maternal smoking in associations with conduct problems and crime: the pelotas 1993 birth cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947962/ https://www.ncbi.nlm.nih.gov/pubmed/27426045 http://dx.doi.org/10.1038/srep29900 |
work_keys_str_mv | AT salatinooliveiraangelica comtandprenatalmaternalsmokinginassociationswithconductproblemsandcrimethepelotas1993birthcohortstudy AT murrayjoseph comtandprenatalmaternalsmokinginassociationswithconductproblemsandcrimethepelotas1993birthcohortstudy AT kielingchristian comtandprenatalmaternalsmokinginassociationswithconductproblemsandcrimethepelotas1993birthcohortstudy AT genrojuliapasqualini comtandprenatalmaternalsmokinginassociationswithconductproblemsandcrimethepelotas1993birthcohortstudy AT polanczykguilherme comtandprenatalmaternalsmokinginassociationswithconductproblemsandcrimethepelotas1993birthcohortstudy AT anselmiluciana comtandprenatalmaternalsmokinginassociationswithconductproblemsandcrimethepelotas1993birthcohortstudy AT wehrmeisterfernando comtandprenatalmaternalsmokinginassociationswithconductproblemsandcrimethepelotas1993birthcohortstudy AT debarrosfernandoc comtandprenatalmaternalsmokinginassociationswithconductproblemsandcrimethepelotas1993birthcohortstudy AT menezesanamariabaptista comtandprenatalmaternalsmokinginassociationswithconductproblemsandcrimethepelotas1993birthcohortstudy AT rohdeluisaugusto comtandprenatalmaternalsmokinginassociationswithconductproblemsandcrimethepelotas1993birthcohortstudy AT hutzmarahelena comtandprenatalmaternalsmokinginassociationswithconductproblemsandcrimethepelotas1993birthcohortstudy |