The Genomic Basis of Parasitism in the Strongyloides Clade of Nematodes

Soil transmitted nematodes, including Strongyloides, cause one of the most prevalent Neglected Tropical Diseases. Here we compare the genomes of four Strongyloides spp., including the human pathogen S. stercoralis, and their close relatives that are facultatively parasitic (Parastrongyloides trichos...

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Detalles Bibliográficos
Autores principales: Hunt, Vicky L., Tsai, Isheng J., Coghlan, Avril, Reid, Adam J., Holroyd, Nancy, Foth, Bernardo J., Tracey, Alan, Cotton, James A., Stanley, Eleanor J., Beasley, Helen, Bennett, Hayley M., Brooks, Karen, Harsha, Bhavana, Kajitani, Rei, Kulkarni, Arpita, Harbecke, Dorothee, Nagayasu, Eiji, Nichol, Sarah, Ogura, Yoshitoshi, Quail, Michael A., Randle, Nadine, Xia, Dong, Brattig, Norbert W., Soblik, Hanns, Ribeiro, Diogo M., Sanchez-Flores, Alejandro, Hayashi, Tetsuya, Itoh, Takehiko, Denver, Dee R., Grant, Warwick, Stoltzfus, Jonathan D., Lok, James B., Murayama, Haruhiko, Wastling, Jonathan, Streit, Adrian, Kikuchi, Taisei, Viney, Mark, Berriman, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948059/
https://www.ncbi.nlm.nih.gov/pubmed/26829753
http://dx.doi.org/10.1038/ng.3495
Descripción
Sumario:Soil transmitted nematodes, including Strongyloides, cause one of the most prevalent Neglected Tropical Diseases. Here we compare the genomes of four Strongyloides spp., including the human pathogen S. stercoralis, and their close relatives that are facultatively parasitic (Parastrongyloides trichosuri) and free-living (Rhabditophanes sp). A significant paralogous expansion of key gene families – astacin-like and SCP/TAPS coding gene families – is associated with the evolution of parasitism in this clade. Exploiting the unique Strongyloides life cycle we compare the transcriptome of its parasitic and free-living stages and find that these same genes are upregulated in the parasitic stages, underscoring their role in nematode parasitism.

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