The Genomic Basis of Parasitism in the Strongyloides Clade of Nematodes

Soil transmitted nematodes, including Strongyloides, cause one of the most prevalent Neglected Tropical Diseases. Here we compare the genomes of four Strongyloides spp., including the human pathogen S. stercoralis, and their close relatives that are facultatively parasitic (Parastrongyloides trichos...

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Autores principales: Hunt, Vicky L., Tsai, Isheng J., Coghlan, Avril, Reid, Adam J., Holroyd, Nancy, Foth, Bernardo J., Tracey, Alan, Cotton, James A., Stanley, Eleanor J., Beasley, Helen, Bennett, Hayley M., Brooks, Karen, Harsha, Bhavana, Kajitani, Rei, Kulkarni, Arpita, Harbecke, Dorothee, Nagayasu, Eiji, Nichol, Sarah, Ogura, Yoshitoshi, Quail, Michael A., Randle, Nadine, Xia, Dong, Brattig, Norbert W., Soblik, Hanns, Ribeiro, Diogo M., Sanchez-Flores, Alejandro, Hayashi, Tetsuya, Itoh, Takehiko, Denver, Dee R., Grant, Warwick, Stoltzfus, Jonathan D., Lok, James B., Murayama, Haruhiko, Wastling, Jonathan, Streit, Adrian, Kikuchi, Taisei, Viney, Mark, Berriman, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948059/
https://www.ncbi.nlm.nih.gov/pubmed/26829753
http://dx.doi.org/10.1038/ng.3495
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author Hunt, Vicky L.
Tsai, Isheng J.
Coghlan, Avril
Reid, Adam J.
Holroyd, Nancy
Foth, Bernardo J.
Tracey, Alan
Cotton, James A.
Stanley, Eleanor J.
Beasley, Helen
Bennett, Hayley M.
Brooks, Karen
Harsha, Bhavana
Kajitani, Rei
Kulkarni, Arpita
Harbecke, Dorothee
Nagayasu, Eiji
Nichol, Sarah
Ogura, Yoshitoshi
Quail, Michael A.
Randle, Nadine
Xia, Dong
Brattig, Norbert W.
Soblik, Hanns
Ribeiro, Diogo M.
Sanchez-Flores, Alejandro
Hayashi, Tetsuya
Itoh, Takehiko
Denver, Dee R.
Grant, Warwick
Stoltzfus, Jonathan D.
Lok, James B.
Murayama, Haruhiko
Wastling, Jonathan
Streit, Adrian
Kikuchi, Taisei
Viney, Mark
Berriman, Matthew
author_facet Hunt, Vicky L.
Tsai, Isheng J.
Coghlan, Avril
Reid, Adam J.
Holroyd, Nancy
Foth, Bernardo J.
Tracey, Alan
Cotton, James A.
Stanley, Eleanor J.
Beasley, Helen
Bennett, Hayley M.
Brooks, Karen
Harsha, Bhavana
Kajitani, Rei
Kulkarni, Arpita
Harbecke, Dorothee
Nagayasu, Eiji
Nichol, Sarah
Ogura, Yoshitoshi
Quail, Michael A.
Randle, Nadine
Xia, Dong
Brattig, Norbert W.
Soblik, Hanns
Ribeiro, Diogo M.
Sanchez-Flores, Alejandro
Hayashi, Tetsuya
Itoh, Takehiko
Denver, Dee R.
Grant, Warwick
Stoltzfus, Jonathan D.
Lok, James B.
Murayama, Haruhiko
Wastling, Jonathan
Streit, Adrian
Kikuchi, Taisei
Viney, Mark
Berriman, Matthew
author_sort Hunt, Vicky L.
collection PubMed
description Soil transmitted nematodes, including Strongyloides, cause one of the most prevalent Neglected Tropical Diseases. Here we compare the genomes of four Strongyloides spp., including the human pathogen S. stercoralis, and their close relatives that are facultatively parasitic (Parastrongyloides trichosuri) and free-living (Rhabditophanes sp). A significant paralogous expansion of key gene families – astacin-like and SCP/TAPS coding gene families – is associated with the evolution of parasitism in this clade. Exploiting the unique Strongyloides life cycle we compare the transcriptome of its parasitic and free-living stages and find that these same genes are upregulated in the parasitic stages, underscoring their role in nematode parasitism.
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spelling pubmed-49480592016-08-10 The Genomic Basis of Parasitism in the Strongyloides Clade of Nematodes Hunt, Vicky L. Tsai, Isheng J. Coghlan, Avril Reid, Adam J. Holroyd, Nancy Foth, Bernardo J. Tracey, Alan Cotton, James A. Stanley, Eleanor J. Beasley, Helen Bennett, Hayley M. Brooks, Karen Harsha, Bhavana Kajitani, Rei Kulkarni, Arpita Harbecke, Dorothee Nagayasu, Eiji Nichol, Sarah Ogura, Yoshitoshi Quail, Michael A. Randle, Nadine Xia, Dong Brattig, Norbert W. Soblik, Hanns Ribeiro, Diogo M. Sanchez-Flores, Alejandro Hayashi, Tetsuya Itoh, Takehiko Denver, Dee R. Grant, Warwick Stoltzfus, Jonathan D. Lok, James B. Murayama, Haruhiko Wastling, Jonathan Streit, Adrian Kikuchi, Taisei Viney, Mark Berriman, Matthew Nat Genet Article Soil transmitted nematodes, including Strongyloides, cause one of the most prevalent Neglected Tropical Diseases. Here we compare the genomes of four Strongyloides spp., including the human pathogen S. stercoralis, and their close relatives that are facultatively parasitic (Parastrongyloides trichosuri) and free-living (Rhabditophanes sp). A significant paralogous expansion of key gene families – astacin-like and SCP/TAPS coding gene families – is associated with the evolution of parasitism in this clade. Exploiting the unique Strongyloides life cycle we compare the transcriptome of its parasitic and free-living stages and find that these same genes are upregulated in the parasitic stages, underscoring their role in nematode parasitism. 2016-02-01 2016-03 /pmc/articles/PMC4948059/ /pubmed/26829753 http://dx.doi.org/10.1038/ng.3495 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Hunt, Vicky L.
Tsai, Isheng J.
Coghlan, Avril
Reid, Adam J.
Holroyd, Nancy
Foth, Bernardo J.
Tracey, Alan
Cotton, James A.
Stanley, Eleanor J.
Beasley, Helen
Bennett, Hayley M.
Brooks, Karen
Harsha, Bhavana
Kajitani, Rei
Kulkarni, Arpita
Harbecke, Dorothee
Nagayasu, Eiji
Nichol, Sarah
Ogura, Yoshitoshi
Quail, Michael A.
Randle, Nadine
Xia, Dong
Brattig, Norbert W.
Soblik, Hanns
Ribeiro, Diogo M.
Sanchez-Flores, Alejandro
Hayashi, Tetsuya
Itoh, Takehiko
Denver, Dee R.
Grant, Warwick
Stoltzfus, Jonathan D.
Lok, James B.
Murayama, Haruhiko
Wastling, Jonathan
Streit, Adrian
Kikuchi, Taisei
Viney, Mark
Berriman, Matthew
The Genomic Basis of Parasitism in the Strongyloides Clade of Nematodes
title The Genomic Basis of Parasitism in the Strongyloides Clade of Nematodes
title_full The Genomic Basis of Parasitism in the Strongyloides Clade of Nematodes
title_fullStr The Genomic Basis of Parasitism in the Strongyloides Clade of Nematodes
title_full_unstemmed The Genomic Basis of Parasitism in the Strongyloides Clade of Nematodes
title_short The Genomic Basis of Parasitism in the Strongyloides Clade of Nematodes
title_sort genomic basis of parasitism in the strongyloides clade of nematodes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948059/
https://www.ncbi.nlm.nih.gov/pubmed/26829753
http://dx.doi.org/10.1038/ng.3495
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