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Use of Follicular Output Rate to Predict Intracytoplasmic Sperm Injection Outcome
BACKGROUND: The measurement of follicular output rate (FORT) has been proposed as a good indicator for evaluating follicular response to the exogenous recombinant folliclestimulating hormone (rFSH). This places FORT as a promising qualitative marker for ovarian function. The objective of the study w...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royan Institute
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948068/ https://www.ncbi.nlm.nih.gov/pubmed/27441049 |
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author | Rehman, Rehana Mustafa, Rozina Baig, Mukhtiar Arif, Sara Hashmi, Muhammad Faisal |
author_facet | Rehman, Rehana Mustafa, Rozina Baig, Mukhtiar Arif, Sara Hashmi, Muhammad Faisal |
author_sort | Rehman, Rehana |
collection | PubMed |
description | BACKGROUND: The measurement of follicular output rate (FORT) has been proposed as a good indicator for evaluating follicular response to the exogenous recombinant folliclestimulating hormone (rFSH). This places FORT as a promising qualitative marker for ovarian function. The objective of the study was to determine FORT as a predictor of oocyte competence, embryo quality and clinical pregnancy after intracytoplasmic sperm injection (ICSI). MATERIALS AND METHODS: This prospective study was carried out on a group of infer- tile females (n=282) at Islamabad Clinic Serving Infertile Couples, Islamabad, Pakistan, from June 2010 till August 2013. Downregulated females were stimulated in injection gonadotropins and on ovulation induction day, pre-ovulatory follicle count (PFC) was determined using transvaginal ultrasound scan (TVUS), and FORT was determined as a ratio of PFC to antral follicle count (AFC)×100. Group I consisted of females with a negative pregnancy test, while group II had a positive pregnancy test that was confirmed with the appearance of fetal cardiac activity. Linear regression analyses of categorical variables of clinical pregnancy along with other independent variables, including FORT, were performed using SPSS version 15.0. RESULTS: Pregnancy occurred in 101/282 women who were tested, recording a clinical pregnancy rate of about 35.8%. FORT values were higher in group II as compared to group I females (P=0.0001). In multiple regression analysis, 97.7, 87.1, 78.2, and 83.4% variations were explained based on the number of retrieved oocytes per patients, number of metaphase II oocytes retrieved, number of fertilized oocytes, and number of cleaved embryos, respectively, indicating FORT as an independent predictor. CONCLUSION: FORT is a predictor of oocyte competence in terms of a number of retrieved, mature and fertilized oocytes. It also gives information about the number of cleaved embryos and clinical pregnancy rate. |
format | Online Article Text |
id | pubmed-4948068 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Royan Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-49480682016-07-20 Use of Follicular Output Rate to Predict Intracytoplasmic Sperm Injection Outcome Rehman, Rehana Mustafa, Rozina Baig, Mukhtiar Arif, Sara Hashmi, Muhammad Faisal Int J Fertil Steril Original Article BACKGROUND: The measurement of follicular output rate (FORT) has been proposed as a good indicator for evaluating follicular response to the exogenous recombinant folliclestimulating hormone (rFSH). This places FORT as a promising qualitative marker for ovarian function. The objective of the study was to determine FORT as a predictor of oocyte competence, embryo quality and clinical pregnancy after intracytoplasmic sperm injection (ICSI). MATERIALS AND METHODS: This prospective study was carried out on a group of infer- tile females (n=282) at Islamabad Clinic Serving Infertile Couples, Islamabad, Pakistan, from June 2010 till August 2013. Downregulated females were stimulated in injection gonadotropins and on ovulation induction day, pre-ovulatory follicle count (PFC) was determined using transvaginal ultrasound scan (TVUS), and FORT was determined as a ratio of PFC to antral follicle count (AFC)×100. Group I consisted of females with a negative pregnancy test, while group II had a positive pregnancy test that was confirmed with the appearance of fetal cardiac activity. Linear regression analyses of categorical variables of clinical pregnancy along with other independent variables, including FORT, were performed using SPSS version 15.0. RESULTS: Pregnancy occurred in 101/282 women who were tested, recording a clinical pregnancy rate of about 35.8%. FORT values were higher in group II as compared to group I females (P=0.0001). In multiple regression analysis, 97.7, 87.1, 78.2, and 83.4% variations were explained based on the number of retrieved oocytes per patients, number of metaphase II oocytes retrieved, number of fertilized oocytes, and number of cleaved embryos, respectively, indicating FORT as an independent predictor. CONCLUSION: FORT is a predictor of oocyte competence in terms of a number of retrieved, mature and fertilized oocytes. It also gives information about the number of cleaved embryos and clinical pregnancy rate. Royan Institute 2016 2016-06-01 /pmc/articles/PMC4948068/ /pubmed/27441049 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Rehman, Rehana Mustafa, Rozina Baig, Mukhtiar Arif, Sara Hashmi, Muhammad Faisal Use of Follicular Output Rate to Predict Intracytoplasmic Sperm Injection Outcome |
title | Use of Follicular Output Rate to Predict Intracytoplasmic
Sperm Injection Outcome |
title_full | Use of Follicular Output Rate to Predict Intracytoplasmic
Sperm Injection Outcome |
title_fullStr | Use of Follicular Output Rate to Predict Intracytoplasmic
Sperm Injection Outcome |
title_full_unstemmed | Use of Follicular Output Rate to Predict Intracytoplasmic
Sperm Injection Outcome |
title_short | Use of Follicular Output Rate to Predict Intracytoplasmic
Sperm Injection Outcome |
title_sort | use of follicular output rate to predict intracytoplasmic
sperm injection outcome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948068/ https://www.ncbi.nlm.nih.gov/pubmed/27441049 |
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