Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis

Most African trypanosomes, including the veterinary species Trypanosoma brucei brucei and T. congolense are susceptible to lysis by human serum. A recent study by Alsford et al. [PLoS Pathogens (2014) 10, e1004130] has identified a T. b. brucei lysosomal cathepsin with an inhibitory effect on human...

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Detalles Bibliográficos
Autor principal: Alsford, Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2014
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948671/
https://www.ncbi.nlm.nih.gov/pubmed/27441199
http://dx.doi.org/10.15698/mic2014.08.162
Descripción
Sumario:Most African trypanosomes, including the veterinary species Trypanosoma brucei brucei and T. congolense are susceptible to lysis by human serum. A recent study by Alsford et al. [PLoS Pathogens (2014) 10, e1004130] has identified a T. b. brucei lysosomal cathepsin with an inhibitory effect on human serum’s trypanolytic action.

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