Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis

Most African trypanosomes, including the veterinary species Trypanosoma brucei brucei and T. congolense are susceptible to lysis by human serum. A recent study by Alsford et al. [PLoS Pathogens (2014) 10, e1004130] has identified a T. b. brucei lysosomal cathepsin with an inhibitory effect on human...

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Detalles Bibliográficos
Autor principal: Alsford, Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2014
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948671/
https://www.ncbi.nlm.nih.gov/pubmed/27441199
http://dx.doi.org/10.15698/mic2014.08.162
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author Alsford, Sam
author_facet Alsford, Sam
author_sort Alsford, Sam
collection PubMed
description Most African trypanosomes, including the veterinary species Trypanosoma brucei brucei and T. congolense are susceptible to lysis by human serum. A recent study by Alsford et al. [PLoS Pathogens (2014) 10, e1004130] has identified a T. b. brucei lysosomal cathepsin with an inhibitory effect on human serum’s trypanolytic action.
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spelling pubmed-49486712016-07-18 Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis Alsford, Sam Microb Cell Microbiology Most African trypanosomes, including the veterinary species Trypanosoma brucei brucei and T. congolense are susceptible to lysis by human serum. A recent study by Alsford et al. [PLoS Pathogens (2014) 10, e1004130] has identified a T. b. brucei lysosomal cathepsin with an inhibitory effect on human serum’s trypanolytic action. Shared Science Publishers OG 2014-07-14 /pmc/articles/PMC4948671/ /pubmed/27441199 http://dx.doi.org/10.15698/mic2014.08.162 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
spellingShingle Microbiology
Alsford, Sam
Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis
title Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis
title_full Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis
title_fullStr Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis
title_full_unstemmed Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis
title_short Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis
title_sort increased trypanosoma brucei cathepsin-l activity inhibits human serum-mediated trypanolysis
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948671/
https://www.ncbi.nlm.nih.gov/pubmed/27441199
http://dx.doi.org/10.15698/mic2014.08.162
work_keys_str_mv AT alsfordsam increasedtrypanosomabruceicathepsinlactivityinhibitshumanserummediatedtrypanolysis

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