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Antibody humanization by molecular dynamics simulations—in‐silico guided selection of critical backmutations
Monoclonal antibodies represent the fastest growing class of biotherapeutic proteins. However, as they are often initially derived from rodent organisms, there is a severe risk of immunogenic reactions, hampering their applicability. The humanization of these antibodies remains a challenging task in...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948679/ https://www.ncbi.nlm.nih.gov/pubmed/26748949 http://dx.doi.org/10.1002/jmr.2527 |