Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism

Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is a key enzyme in triacylglycerol (TG) biosynthesis. Here we show that genetic deficiency and pharmacological inhibition of DGAT1 in mice alters cholesterol metabolism. Cholesterol absorption, as assessed by acute cholesterol uptake, was significant...

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Detalles Bibliográficos
Autores principales: Sachdev, Vinay, Leopold, Christina, Bauer, Raimund, Patankar, Jay V., Iqbal, Jahangir, Obrowsky, Sascha, Boverhof, Renze, Doktorova, Marcela, Scheicher, Bernhard, Goeritzer, Madeleine, Kolb, Dagmar, Turnbull, Andrew V., Zimmer, Andreas, Hoefler, Gerald, Hussain, M. Mahmood, Groen, Albert K., Kratky, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948681/
https://www.ncbi.nlm.nih.gov/pubmed/27344248
http://dx.doi.org/10.1016/j.bbalip.2016.06.014

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