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A MutSβ-Dependent Contribution of MutSα to Repeat Expansions in Fragile X Premutation Mice?
The fragile X-related disorders result from expansion of a CGG/CCG microsatellite in the 5’ UTR of the FMR1 gene. We have previously demonstrated that the MSH2/MSH3 complex, MutSβ, that is important for mismatch repair, is essential for almost all expansions in a mouse model of these disorders. Here...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948851/ https://www.ncbi.nlm.nih.gov/pubmed/27427765 http://dx.doi.org/10.1371/journal.pgen.1006190 |