Cargando…

XRP44X, an Inhibitor of Ras/Erk Activation of the Transcription Factor Elk3, Inhibits Tumour Growth and Metastasis in Mice

Transcription factors have an important role in cancer but are difficult targets for the development of tumour therapies. These factors include the Ets family, and in this study Elk3 that is activated by Ras oncogene /Erk signalling, and is involved in angiogenesis, malignant progression and epithel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Semenchenko, Kostyantyn, Wasylyk, Christine, Cheung, Henry, Tourrette, Yves, Maas, Peter, Schalken, Jack A, van der Pluijm, Gabri, Wasylyk, Bohdan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948895/ https://www.ncbi.nlm.nih.gov/pubmed/27427904 http://dx.doi.org/10.1371/journal.pone.0159531

Ejemplares similares

Tubulin Tyrosine Ligase Like 12, a TTLL Family Member with SET- and TTL-Like Domains and Roles in Histone and Tubulin Modifications and Mitosis
por: Brants, Jan, et al.
Publicado: (2012)

The Oncogenic MicroRNA Hsa-miR-155-5p Targets the Transcription Factor ELK3 and Links It to the Hypoxia Response
por: Robertson, E. Douglas, et al.
Publicado: (2014)

Elk3 Deficiency Causes Transient Impairment in Post-Natal Retinal Vascular Development and Formation of Tortuous Arteries in Adult Murine Retinae
por: Weinl, Christine, et al.
Publicado: (2014)

CTIP2 Expression in Human Head and Neck Squamous Cell Carcinoma Is Linked to Poorly Differentiated Tumor Status
por: Ganguli-Indra, Gitali, et al.
Publicado: (2009)

Correction: CTIP2 Expression in Human Head and Neck Squamous Cell Carcinoma Is Linked to Poorly Differentiated Tumor Status
por: Ganguli-Indra, Gitali, et al.
Publicado: (2009)

Research progress on antitumor activity of XRP44X and analogues as microtubule targeting agents
por: Wang, Chao, et al.
Publicado: (2023)

An easy method for preparation of Cre-loxP regulated fluorescent adenoviral expression vectors and its application for direct reprogramming into hepatocytes
por: Kurihara, Chitose, et al.
Publicado: (2016)

A new look towards BAC-based array CGH through a comprehensive comparison with oligo-based array CGH
por: Wicker, Nicolas, et al.
Publicado: (2007)

ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines
por: Ayoub, C, et al.
Publicado: (2010)

Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma
por: Lemaire, F, et al.
Publicado: (2004)

Cryptoasset networks: Flows and regular players in Bitcoin and XRP
por: Aoyama, Hideaki, et al.
Publicado: (2022)

Preferential Response of Basal-Like Head and Neck Squamous Cell Carcinoma Cell Lines to EGFR-Targeted Therapy Depending on EREG-Driven Oncogenic Addiction
por: Job, Sylvie, et al.
Publicado: (2019)

Regulation of MCP-1 chemokine transcription by p53
por: Hacke, Katrin, et al.
Publicado: (2010)

XRP44X Enhances the Cytotoxic Activity of Natural Killer Cells by Activating the c-JUN N-Terminal Kinase Signaling Pathway
por: Kim, Kwang-Soo, et al.
Publicado: (2020)

NLK is required for Ras/ERK/SRF/ELK signaling to tune skeletal muscle development by phosphorylating SRF and antagonizing the SRF/MKL pathway
por: Li, Shang-Ze, et al.
Publicado: (2022)

Projecting XRP price burst by correlation tensor spectra of transaction networks
por: Chakraborty, Abhijit, et al.
Publicado: (2023)

EM-Measurements and Evaluation of the XRP (Roman Pot to be installed with UA9 Experiment)
por: Farricker, Aaron, et al.
Publicado: (2017)

Differential expression profiling of head and neck squamous cell carcinoma (HNSCC)
por: Lemaire, F, et al.
Publicado: (2003)

Ripple quick start guide: get started with XRP and develop applications on Ripple's blockchain
por: James, Febin John
Publicado: (2018)

Drosophila RpS12 controls translation, growth, and cell competition through Xrp1
por: Ji, Zhejun, et al.
Publicado: (2019)

The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila
por: Brown, Brian, et al.
Publicado: (2021)

ERK Signaling Controls Innate-like CD8(+) T Cell Differentiation via the ELK4 (SAP-1) and ELK1 Transcription Factors
por: Maurice, Diane, et al.
Publicado: (2018)

Integrin-Mediated Adhesion Regulates ERK Nuclear Translocation and Phosphorylation of Elk-1
por: Aplin, Andrew E., et al.
Publicado: (2001)

MTBP inhibits the Erk1/2-Elk-1 signaling in hepatocellular carcinoma
por: Ranjan, Atul, et al.
Publicado: (2018)

Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma
por: Muller, D, et al.
Publicado: (2006)

The role of microRNAs in bone metastasis
por: Zoni, Eugenio, et al.
Publicado: (2016)

Xrp1 genetically interacts with the ALS-associated FUS orthologue caz and mediates its toxicity
por: Mallik, Moushami, et al.
Publicado: (2018)

Xrp1 is a transcription factor required for cell competition-driven elimination of loser cells
por: Baillon, Ludovic, et al.
Publicado: (2018)

Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α
por: Ochi, Naotaka, et al.
Publicado: (2021)

PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axis
por: Rodriguez-Aguayo, Cristian, et al.
Publicado: (2019)

The Identification of Small Molecule Inhibitors That Reduce Invasion and Metastasis of Aggressive Cancers
por: van de Merbel, Arjanneke F., et al.
Publicado: (2021)

RAS Dimers: The Novice Couple at the RAS-ERK Pathway Ball
por: Herrero, Ana, et al.
Publicado: (2021)

Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status
por: Langton, Paul F., et al.
Publicado: (2021)

Mitogen-induced recruitment of ERK and MSK to SRE promoter complexes by ternary complex factor Elk-1
por: Zhang, Hong-Mei, et al.
Publicado: (2008)

The Role of EGFR/ERK/ELK-1 MAP Kinase Pathway in the Underlying Damage to Diabetic Rat Skin
por: Ge, Xinhong, et al.
Publicado: (2013)

ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1
por: Galbraith, Matthew D., et al.
Publicado: (2013)

The Drosophila FUS ortholog cabeza promotes adult founder myoblast selection by Xrp1-dependent regulation of FGF signaling
por: Catinozzi, Marica, et al.
Publicado: (2020)

The transcription factor Xrp1 orchestrates both reduced translation and cell competition upon defective ribosome assembly or function
por: Kiparaki, Marianthi, et al.
Publicado: (2022)

Loss of Paip1 causes translation reduction and induces apoptotic cell death through ISR activation and Xrp1
por: Xue, Maoguang, et al.
Publicado: (2023)

A computationally engineered RAS rheostat reveals RAS/ERK signaling dynamics
por: Rose, John C., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_0e7kfps4dl4o3qfv4lj44dm6li