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THE ROLE OF CYSTEINE PROTEASE IN ALZHEIMER DISEASE

INTRODUCTION: Cysteine protease are biological catalysts which play a pivotal role in numerous biological reactions in organism. Much of the literature is inscribed to their biochemical significance, distribution and mechanism of action. Many diseases, e.g. Alzheimer’s disease, develop due to enzyme...

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Autores principales: Hasanbasic, Samra, Jahic, Alma, Karahmet, Emina, Sejranic, Asja, Prnjavorac, Besim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AVICENA, d.o.o., Sarajevo 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949049/
https://www.ncbi.nlm.nih.gov/pubmed/27482169
http://dx.doi.org/10.5455/msm.2016.28.235-238
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author Hasanbasic, Samra
Jahic, Alma
Karahmet, Emina
Sejranic, Asja
Prnjavorac, Besim
author_facet Hasanbasic, Samra
Jahic, Alma
Karahmet, Emina
Sejranic, Asja
Prnjavorac, Besim
author_sort Hasanbasic, Samra
collection PubMed
description INTRODUCTION: Cysteine protease are biological catalysts which play a pivotal role in numerous biological reactions in organism. Much of the literature is inscribed to their biochemical significance, distribution and mechanism of action. Many diseases, e.g. Alzheimer’s disease, develop due to enzyme balance disruption. Understanding of cysteine protease’s disbalance is therefor a key to unravel the new possibilities of treatment. Cysteine protease are one of the most important enzymes for protein disruption during programmed cell death. Whether protein disruption is part of cell deaths is not enough clear in any cases. Thereafter, any tissue disruption, including proteolysis, generate more or less inflammation appearance. REVIEW: This review briefly summarizes the current knowledge about pathological mechanism’s that results in AD, with significant reference to the role of cysteine protease in it. Based on the summary, new pharmacological approach and development of novel potent drugs with selective toxicity targeting cysteine protease will be a major challenge in years to come.
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spelling pubmed-49490492016-08-01 THE ROLE OF CYSTEINE PROTEASE IN ALZHEIMER DISEASE Hasanbasic, Samra Jahic, Alma Karahmet, Emina Sejranic, Asja Prnjavorac, Besim Mater Sociomed Review INTRODUCTION: Cysteine protease are biological catalysts which play a pivotal role in numerous biological reactions in organism. Much of the literature is inscribed to their biochemical significance, distribution and mechanism of action. Many diseases, e.g. Alzheimer’s disease, develop due to enzyme balance disruption. Understanding of cysteine protease’s disbalance is therefor a key to unravel the new possibilities of treatment. Cysteine protease are one of the most important enzymes for protein disruption during programmed cell death. Whether protein disruption is part of cell deaths is not enough clear in any cases. Thereafter, any tissue disruption, including proteolysis, generate more or less inflammation appearance. REVIEW: This review briefly summarizes the current knowledge about pathological mechanism’s that results in AD, with significant reference to the role of cysteine protease in it. Based on the summary, new pharmacological approach and development of novel potent drugs with selective toxicity targeting cysteine protease will be a major challenge in years to come. AVICENA, d.o.o., Sarajevo 2016-06 2016-06-01 /pmc/articles/PMC4949049/ /pubmed/27482169 http://dx.doi.org/10.5455/msm.2016.28.235-238 Text en Copyright: © 2016 Samra Hasanbasic, Alma Jahic, Emina Karahmet, Asja Sejranic, and Besim Prnjavorac http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Hasanbasic, Samra
Jahic, Alma
Karahmet, Emina
Sejranic, Asja
Prnjavorac, Besim
THE ROLE OF CYSTEINE PROTEASE IN ALZHEIMER DISEASE
title THE ROLE OF CYSTEINE PROTEASE IN ALZHEIMER DISEASE
title_full THE ROLE OF CYSTEINE PROTEASE IN ALZHEIMER DISEASE
title_fullStr THE ROLE OF CYSTEINE PROTEASE IN ALZHEIMER DISEASE
title_full_unstemmed THE ROLE OF CYSTEINE PROTEASE IN ALZHEIMER DISEASE
title_short THE ROLE OF CYSTEINE PROTEASE IN ALZHEIMER DISEASE
title_sort role of cysteine protease in alzheimer disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949049/
https://www.ncbi.nlm.nih.gov/pubmed/27482169
http://dx.doi.org/10.5455/msm.2016.28.235-238
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